Gallic Acid-Loaded Gel Formulation Combats Skin Oxidative Stress: Development, Characterization and Ex Vivo Biological Assays

Gallic Acid-Loaded Gel Formulation Combats Skin Oxidative Stress: Development, Characterization and Ex Vivo Biological Assays

Author Monteiro e Silva, Silas Arandas Autor UNIFESP Google Scholar
Fioramonti Calixto, Giovana Maria Google Scholar
Cajado, Juliana Google Scholar
Antunes de Carvalho, Patricia Caballieri Autor UNIFESP Google Scholar
Rodero, Camila Fernanda Google Scholar
Chorilli, Marlus Google Scholar
Leonardi, Gislaine Ricci Autor UNIFESP Google Scholar
Abstract Oxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of naturally occurring antioxidants. They have emerged as strong antioxidants that can be used as active cosmetics. The purpose of this study was to develop a gallic acid-loaded cosmetic gel formulation and characterize it using rheological, mechanical, and bioadhesive tests. Its antioxidant effect in the stratumcorneumwas evaluated by a non-invasivemethod. According to the characterization tests, the formulation exhibited skin adhesiveness and pseudoplastic behavior without thixotropy, rendering it suitable for use as a cosmetic formulation. Furthermore, the non-invasive method indicated the antioxidant effect in the stratum corneum, with the global lipid peroxide reduction being 33.97 +/- 11.66%. Thus, we were able to develop a promising gallic acid-loaded gel formulation that could reduce lipid peroxides and thus combat skin oxidative stress.
Keywords antioxidants
gallic acid
polymers
skin administration
Language English
Sponsor Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Programa de Apoio ao Desenvolvimento Científico-Faculdade de Ciências Farmacêuticas-UNESP (PADC-FCF)
Grant number FAPESP: 2011/04908-1
FAPESP: 2013/01565-1
FAPESP: 2013/01118-5
FAPESP: 2014/24180-0
FAPESP: 2017/17597-0
Date 2017
Published in Polymers. Basel, v. 9, n. 9, p. -, 2017.
ISSN 2073-4360 (Sherpa/Romeo, impact factor)
Publisher Mdpi Ag
Extent -
Origin http://dx.doi.org/10.3390/polym9090391
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000411524400010
URI http://repositorio.unifesp.br/handle/11600/51294

Show full item record




File

Name: WOS000411524400010.pdf
Size: 637.7Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account