Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

Author Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Cardoso, Caroline Margonato Autor UNIFESP Google Scholar
Yujra, Veronica Quispe Autor UNIFESP Google Scholar
Viana, Milena De Barros Autor UNIFESP Google Scholar
Aguiar, Odair, Jr. Autor UNIFESP Google Scholar
Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Fujiyama Oshima, Celina Tizuko Autor UNIFESP Google Scholar
Abstract Apoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features different from other cellular mechanisms of death such as necrosis. In the last years, apoptosis has been extensively studied in the scientific literature, because it has been established that apoptosis plays a crucial role following the time course of chronic degenerative diseases, such as cancer. Thus, several researchers have strugged to detect what chemical agents are able to inter fere with the apoptotic process. Thus, the purpose of this literature review is to assess if fluoride induces apoptosis in mammalian cells using in vivo and in vitro test systems. Certain mammalian cell types such as oral cells, blood and brain were exetensively investigated

the results showed that fluoride is able to induce apoptosis in both intrinsinc and extrinsic pathways. Moreover, other cells types have been poorly investigated such as bone, kidney and reproductive cells with conflicting results so far. Therefore, this area needs further investigation for the safety of human populations exposed to fluoride in a chronic way, as for example in developing countries.
Keywords Fluoride
apoptosis
in vitro studies
in vivo studies
review
Language English
Date 2017
Published in Anticancer Research. Athens, v. 37, n. 9, p. 4767-4777, 2017.
ISSN 0250-7005 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 4767-4777
Origin http://dx.doi.org/10.21873/anticanres.11883
Access rights Closed access
Type Revisão
Web of Science ID WOS:000412578200006
URI http://repositorio.unifesp.br/handle/11600/51256

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