Brazilian guidelines for the clinical management of paracoccidioidomycosis

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Author Shikanai-Yasuda, Maria Aparecida Google Scholar
Mendes, Rinaldo Poncio Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
de Queiroz-Telles, Flavio Google Scholar
Goncalves Kono, Adriana Satie Google Scholar
Paniago, Anamaria M. M. Google Scholar
Nathan, Andre Google Scholar
Francisconi do Valle, Antonio Carlos Google Scholar
Bagagli, Eduardo Google Scholar
Benard, Gil Google Scholar
Ferreira, Marcelo Simao Google Scholar
Teixeira, Marcus de Melo Google Scholar
Silva-Vergara, Mario Leon Google Scholar
Pereira, Ricardo Mendes Google Scholar
Cavalcante, Ricardo de Souza Google Scholar
Hahn, Rosane Google Scholar
Durlacher, Rui Rafael Google Scholar
Khoury, Zarifa Google Scholar
de Camargo, Zoilo Pires Autor UNIFESP Google Scholar
Moretti, Maria Luiza Google Scholar
Martinez, Roberto Google Scholar
Abstract Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis (P. brasiliensis) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii (P. lutzii), has been reported in Rondonia, where the disease has reached epidemic levels, and in the Central West and Para. Accurate diagnoses and availability of antigens that are reactive with the patients' sera remain significant challenges. Therefore, the present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. This consensus summarizes etiological, ecoepidemiological, molecular epidemiological, and immunopathological data, with emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression. The consensus also includes discussion of outpatient treatments, severe disease forms, disease prevalence among special populations and resource-poor settings, a brief review of prevention and control measures, current challenges and recommendations.
Keywords Paracoccidioidomycosis
Clinical management
Treatment follow-up
Language English
Sponsor Brazilian Society of Tropical Medicine and Hygiene
Brazilian Society of Infectology and Sociedade Paulista de Infectologia
Departamento de Moléstias Infecciosas e Parasitárias da FMUSP
Date 2017
Published in Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia, v. 50, n. 5, p. 715-740, 2017.
ISSN 0037-8682 (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Medicina Tropical
Extent 715-740
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000414732300025
SciELO ID S0037-86822017000500715 (statistics in SciELO)

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