Multicenter, Randomized Clinical Trial to Assess the Effectiveness of Intravitreal Injections of Bevacizumab, Triamcinolone, or Their Combination in the Treatment of Diabetic Macular Edema

Multicenter, Randomized Clinical Trial to Assess the Effectiveness of Intravitreal Injections of Bevacizumab, Triamcinolone, or Their Combination in the Treatment of Diabetic Macular Edema

Author Neto, Hermelino O. Autor UNIFESP Google Scholar
Regatieri, Caio V. Autor UNIFESP Google Scholar
Nobrega, Mario J. Google Scholar
Muccioli, Cristina Autor UNIFESP Google Scholar
Casella, Antonio M. Google Scholar
Andrade, Rafael E. Google Scholar
Maia, Mauricio Autor UNIFESP Google Scholar
Kniggendorf, Vinicius Autor UNIFESP Google Scholar
Ferreira, Magno Google Scholar
Branco, Andre C. Google Scholar
Belfort, Rubens, Jr. Autor UNIFESP Google Scholar
Abstract BACKGROUND AND OBJECTIVE: To evaluate the efficacy of combined bevacizumab-triamcinolone intravitreal injection in the treatment of diabetic macular edema (DME) compared to monotherapy. PATIENTS AND METHODS: At eight clinical sites, 111 patients with DME were randomly assigned to receive an intravitreal injection of bevacizumab (Avastin

Genentech, South San Francisco, CA), triamcinolone (Ophthalmos Pharmaceutical Industry, Sao Paulo-SP, Brazil), or their combination. The primary outcome was visual acuity (VA) at 6 months' follow-up. RESULTS: The average number of injections was 3.2 in the bevacizumab group, 2.4 in the combined group, and 2.1 in the triamcinolone group. All groups presented with improvements in VA (P < .001)

however, no differences between groups were observed (P =.436). Mean reduction in central retinal thickness was statistically different only between the triamcinolone and bevacizumab groups (P < .015). CONCLUSION: Mono-or combination therapy was effective for DME treatment. No synergistic effects were observed

however, triamcinolone alone or a drug combination may reduce the number of injections required when compared to bevacizumab alone.
Language English
Sponsor Sao Paulo Research Foundation
Date 2017
Published in Ophthalmic Surgery Lasers & Imaging Retina. Thorofare, v. 48, n. 9, p. 734-740, 2017.
ISSN 2325-8160 (Sherpa/Romeo, impact factor)
Publisher Slack Inc
Extent 734-740
Origin http://dx.doi.org/10.3928/23258160-20170829-08
Access rights Closed access
Type Article
Web of Science ID WOS:000416072300007
URI http://repositorio.unifesp.br/handle/11600/51248

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