Clinical utility of F-18-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma

Clinical utility of F-18-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma

Author Yang, Ji H. Autor UNIFESP Google Scholar
Maciel, Rui M. B. Autor UNIFESP Google Scholar
Nakabashi, Claudia C. D. Autor UNIFESP Google Scholar
Janovsky, Carolina C. P. S. Autor UNIFESP Google Scholar
Padovani, Rosalia P. Autor UNIFESP Google Scholar
Macellaro, Danielle Autor UNIFESP Google Scholar
Camacho, Cleber P. Autor UNIFESP Google Scholar
Osawa, Akemi Google Scholar
Wagner, Jairo Google Scholar
Biscolla, Rosa Paula M. Autor UNIFESP Google Scholar
Abstract Objective: To evaluate the clinical utility of F-18-FDG PET/CT in patients with high-risk DTC. Subjects and methods: Single-center retrospective study with 74 patients with high-risk differentiated thyroid cancer (DTC), classified in 4 groups. Group 1: patients with positive sTg or TgAb, subdivided in Group 1A: negative RxWBS and no foci of metastases identified at conventional image (n = 9)

Group 1B: RxWBS not compatible with suspicious foci at conventional image or not proportional to sTg level (n = 13)

Group 2: patients with histological findings of aggressive DTC variants (n = 21) and Group 3: patients with positive RxWBS (n = 31). Results: F-18-FDG PET/CT identified undifferentiated lesions and helped restage the disease in groups 1B and 2. The scan helped guide clinical judgment in 9/13 (69%) patients of group 1B, 10/21 (48%) patients of group 2 and 2/31 (6%) patients of group 3. There was no clinical benefit associated with group 1A. F-18-FDG PET/CT was associated with progressive disease. Conclusion: F-18-FDG PET/CT is a useful tool in the follow-up of patients with high-risk DTC, mainly in the group of RxWBS not compatible with suspicious foci at conventional image or not proportional to sTg level and in those with aggressive DTC variants. Additionally, this study showed that F-18-FDG PET/CT was associated with progression and helped display undifferentiated lesions guiding clinical assessments regarding surgeries or expectant treatments.
Keywords Differentiated thyroid carcinoma
F-18-FDG PET/CT
radioiodine (RAI)
whole-body scan (WBS)
thyroglobulin (Tg)
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Ministério da Saúde (MS)
Grant number FAPESP: 2006/60402-1
MS: 25000.168513/2008-11
Date 2017
Published in Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 5, p. 416-425, 2017.
ISSN 2359-3997 (Sherpa/Romeo, impact factor)
Publisher Sbem-Soc Brasil Endocrinologia & Metabologia
Extent 416-425
Origin http://dx.doi.org/10.1590/2359-3997000000285
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000416002900003
SciELO ID S2359-39972017000500416 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/51245

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