Inter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder

Inter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder

Author Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Santos, Camila M. Autor UNIFESP Google Scholar
Rizzo, Lucas B. Autor UNIFESP Google Scholar
Cunha, Graccielle R. Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Noto, Mariane N. Autor UNIFESP Google Scholar
Pedrini, Mariana Autor UNIFESP Google Scholar
Zeni, Maiara Autor UNIFESP Google Scholar
Cordeiro, Quirino Autor UNIFESP Google Scholar
McIntyre, Roger S. Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Objectives: Accumulating evidence indicates that oxidative stress and neurotrophins have a bidirectional relationship. In this post hoc, exploratory analysis, we investigated the association between plasma brain-derived neurotrophic factor (BDNF) levels and activities of the antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) in individuals with bipolar disorder (BD) and healthy controls. Methods: We measured plasma levels of BDNF and activities of GPx and SOD in individuals with BD (n=59) and healthy controls (n=26). Information related to current and past psychiatric/medical history, as well as to metabolic comorbidities, was also reported. Results: There were negative correlations between BDNF, GPx (r=-.449, P=.001) and GPx/SOD ratio (r=-.503, P<.001), and a positive correlation between BDNF and SOD (r=.254, P=.020). There was a moderating effect of body mass index (BMI) on the association between BDNF and GPx/SOD rate ratio [(RR)=1.002, P=.034]

interactions between impaired glucose metabolism (IGM), GPx (RR=1.016, P=.033), and GPx/SOD ratio (RR=1.026, P=.002) were also observed. These results were significant in models that included age, gender, alcohol, tobacco and medication use. Conclusions: There was a robust and independent correlation between peripheral BDNF and antioxidant enzyme activities in individuals with BD, which was moderated by metabolic comorbidities. These results reinforce the concept that these systems are associated and further extend knowledge of the putative effect of metabolic comorbidities in the pathophysiological substrates of BD.
Keywords bipolar disorder
body mass index
brain-derived neurotrophic factor
oxidative stress
Language English
Date 2016
Published in Bipolar Disorders. Hoboken, v. 18, n. 5, p. 433-439, 2016.
ISSN 1398-5647 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 433-439
Access rights Closed access
Type Article
Web of Science ID WOS:000388307900005

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