Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation

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dc.contributor.author Rodrigues Cunha, Vanessa Roberta
dc.contributor.author de Souza, Rodrigo Barbosa [UNIFESP]
dc.contributor.author Pinto da Fonseca Martins, Ana Maria Cristina Rebello
dc.contributor.author Jun Koh, Ivan Hong [UNIFESP]
dc.contributor.author Leopoldo Constantino, Vera Regina
dc.date.accessioned 2019-07-22T15:46:55Z
dc.date.available 2019-07-22T15:46:55Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1038/srep30547
dc.identifier.citation Scientific Reports. London, v. 6, p. -, 2016.
dc.identifier.issn 2045-2322
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51178
dc.description.abstract Biocompatibility of layered double hydroxides (LDHs), also known as hydrotalcite-like materials or double metal hydroxides, was investigated by in vivo assays via intramuscular tablets implantation in rat abdominal wall. The tablets were composed by chloride ions intercalated into LDH of magnesium/aluminum (Mg2Al-Cl) and zinc/aluminum (Zn2Al-Cl). The antigenicity and tissue integration capacity of LDHs were assessed histologically after 7 and 28 days post-implantation. No fibrous capsule nearby the LDH was noticed for both materials as well any sign of inflammatory reactions. Sidestream Dark Field imaging, used to monitor in real time the microcirculation in tissues, revealed overall integrity of the microcirculatory network neighboring the tablets, with no blood flow obstruction, bleeding and/or increasing of leukocyte endothelial adhesion. After 28 days Mg2Al-Cl promoted multiple collagen invaginations (mostly collagen type-I) among its fragments while Zn2Al-Cl induced predominantly collagen type-III. This work supports previous results in the literature about LDHs compatibility with living matter, endorsing them as functional materials for biomedical applications. en
dc.description.sponsorship Brazilian agency Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [2011/50318-1, 2012/12209-9]
dc.description.sponsorship Brazilian agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq [312384/2013-0]
dc.format.extent -
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights Acesso aberto
dc.title Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation en
dc.type Artigo
dc.description.affiliation Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliation Secretaria Agr & Abastecimento, Inst Biol, Av Conselheiro Rodrigues Alves 1252, BR-04014002 Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Cirurgia, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Cirurgia, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP:2011/50318-1
dc.description.sponsorshipID 2012/12209-9
dc.description.sponsorshipID CNPq:312384/2013-0
dc.identifier.file WOS000380632700001.pdf
dc.identifier.doi 10.1038/srep30547
dc.description.source Web of Science
dc.identifier.wos WOS:000380632700001



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