Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology

Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology

Author Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Cunha, Graccielle R. Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Zeni-Graiff, Maiara Autor UNIFESP Google Scholar
Rios, Adiel C. Autor UNIFESP Google Scholar
Sethi, Sumit Autor UNIFESP Google Scholar
Maurya, Pawan K. Autor UNIFESP Google Scholar
Levandowski, Mateus L. Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Pan, Pedro M. Autor UNIFESP Google Scholar
Stertz, Laura Google Scholar
Belangero, Sintia I. Autor UNIFESP Google Scholar
Anna, Marcia Kauer-Sant' Google Scholar
Teixeira, Antonio L. Google Scholar
Mari, Jair J. Autor UNIFESP Google Scholar
Rohde, Luis A. Google Scholar
Miguel, Euripedes C. Google Scholar
McIntyre, Roger S. Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Background Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF. Methods and Findings Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004

1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028

1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997

1.066, p = 0.077). SED was also significantly associated with all CBCL DSM-oriented scales (all p < 0.05), whereas serum biomarkers (i.e. IL6, TBARS, BDNF) were associated with specific subscales. Moreover, the associations between serum biomarkers and domains of psychopathology were moderated by SED, with stronger correlations between mental health problems, IL6, TBARS, and BDNF being observed in children with high SED. Conclusions In children, SED is highly associated with mental health problems. Our findings suggest that this association may be moderated via effects on multiple interacting neurobiological systems.
Language English
Sponsor National Council for Scientific and Technological Development (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Sao Paulo Research Foundation (FAPESP)
Date 2016
Published in Plos One. San Francisco, v. 11, n. 8, p. -, 2016.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Origin http://dx.doi.org/10.1371/journal.pone.0160455
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000381368900059
URI http://repositorio.unifesp.br/handle/11600/51174

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