The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using Tc-99m-ECD SPECT

The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using Tc-99m-ECD SPECT

Author Laureano, Maura Regina Autor UNIFESP Google Scholar
Onishi, Ektor Tsuneo Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Braga Neto, Pedro Autor UNIFESP Google Scholar
Vieira Castiglioni, Mario Luiz Autor UNIFESP Google Scholar
Batista, Ilza Rosa Autor UNIFESP Google Scholar
Reis, Marilia Alves Autor UNIFESP Google Scholar
Garcia, Michele Vargas Autor UNIFESP Google Scholar
de Andrade, Adriana Neves Autor UNIFESP Google Scholar
Sanchez, Maura Ligia Autor UNIFESP Google Scholar
Moreira, Hugo Cogo Autor UNIFESP Google Scholar
de Almeida, Roberta Ribeiro Autor UNIFESP Google Scholar
Garrido, Griselda Jara Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Abstract Investigate the effect of acupuncture on brain perfusion using ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m-ECD SPECT) in patients with tinnitus. This randomized, single-blind, sham-control study examined patients (18-60 years old) with normal hearing and chronic, idiopathic, continuous tinnitus. Fifty-seven subjects were randomly assigned to true (n = 30) or sham (n = 27) acupuncture (ACP)

Tc-99m-ECD SPECT examinations were performed before and after 12 twice-weekly ACP sessions. Secondary outcomes included changes in the Tinnitus Handicap Inventory (THI), Visual Analog Scale (VAS), Hamilton Anxiety Scale (HAS) and Beck Depression Inventory (BDI). Imaging data were analysed using Statistical Parametric Mapping (SPM8) software. Regression models were used to examine secondary outcomes via two paradigms: intention-to-treat (ITT

where multiple imputations were conducted because of study attrition) and complete cases. No between-group brain perfusion differences were observed. However, a significant improvement in THI scores was observed at the end of true ACP treatment for all domains (all p values < 0.01) except the catastrophic scale. ACP might reduce the effects of tinnitus on daily life

however, additional studies should be conducted to verify the effects of ACP on the neural architecture and brain function of tinnitus patients.
Keywords Hearing
Single-photon emission computerized tomography
Clinical trial
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP-2010/14804-6]
FAPESP [2010/14804-6]
Ethics Committee of Universidade Federal de Sao Paulo [2094/09]
Grant number FAPESP:2010/14804-6
Date 2016
Published in European Radiology. New York, v. 26, n. 9, p. 3234-3242, 2016.
ISSN 0938-7994 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 3234-3242
Access rights Closed access
Type Article
Web of Science ID WOS:000381122400043

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