MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis

Show simple item record Escorcio-Bezerra, Marcio Luiz [UNIFESP] Abrahao, Agessandro [UNIFESP] de Castro, Isac Troccoli Chieia, Marco Antonio [UNIFESP] de Azevedo, Lyamara Apostolico [UNIFESP] Pinheiro, Denise Spinola [UNIFESP] de Oliveira Braga, Nadia Iandoli [UNIFESP] Bulle de Oliveira, Acary Souza [UNIFESP] Manzano, Gilberto Mastrocola [UNIFESP] 2019-07-22T15:46:51Z 2019-07-22T15:46:51Z 2016
dc.identifier.citation Clinical Neurophysiology. Clare, v. 127, n. 9, p. 2979-2984, 2016.
dc.identifier.issn 1388-2457
dc.description.abstract Objective: To study the reproducibility, diagnostic yield to detect denervation, and clinical correlations of the Motor Unit Number Index (MUNIX) in subjects with Amyotrophic Lateral Sclerosis (ALS). Methods: MUNIX evaluation was performed in three muscles twice on the same day to assess reproducibility. Cut-off values for the MUNIX were based on data from 51 healthy subjects (controls) to evaluate the sensitivity of the technique to detect denervation in 30 subjects with ALS. Results: The method had good reproducibility. The variability was greater in the ALS group. In 23 ALS subjects (77%), low MUNIX values were detected. Most of the muscles with low MUNIX had also low compound muscle action potential (CMAP) and strength, but these parameters were normal in 9% of muscles. According to ROC curve analysis, MUNIX was generally accurate (AUC = 0.9504) for discriminating between healthy individuals and subjects with at least one denervated muscle. Conclusions: MUNIX variability was higher in the ALS group. The method showed good diagnostic performance for the detection of denervation in a sample of patients with ALS. Significance: This study demonstrated that in addition to being a quantitative tool MUNIX can detect denervation in subjects with ALS. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 2979-2984
dc.language.iso eng
dc.publisher Elsevier Ireland Ltd
dc.rights Acesso restrito
dc.subject MUNIX en
dc.subject ALS en
dc.subject MUNE en
dc.subject Reproducibility en
dc.subject Clinical correlation en
dc.subject Denervation en
dc.title MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med FMUSP, Div Mol Med, Dept Med, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.clinph.2016.06.011
dc.description.source Web of Science
dc.identifier.wos WOS:000381080400003


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