MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis

Show simple item record

dc.contributor.author Escorcio-Bezerra, Marcio Luiz [UNIFESP]
dc.contributor.author Abrahao, Agessandro [UNIFESP]
dc.contributor.author de Castro, Isac
dc.contributor.author Troccoli Chieia, Marco Antonio [UNIFESP]
dc.contributor.author de Azevedo, Lyamara Apostolico [UNIFESP]
dc.contributor.author Pinheiro, Denise Spinola [UNIFESP]
dc.contributor.author de Oliveira Braga, Nadia Iandoli [UNIFESP]
dc.contributor.author Bulle de Oliveira, Acary Souza [UNIFESP]
dc.contributor.author Manzano, Gilberto Mastrocola [UNIFESP]
dc.date.accessioned 2019-07-22T15:46:51Z
dc.date.available 2019-07-22T15:46:51Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.clinph.2016.06.011
dc.identifier.citation Clinical Neurophysiology. Clare, v. 127, n. 9, p. 2979-2984, 2016.
dc.identifier.issn 1388-2457
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51123
dc.description.abstract Objective: To study the reproducibility, diagnostic yield to detect denervation, and clinical correlations of the Motor Unit Number Index (MUNIX) in subjects with Amyotrophic Lateral Sclerosis (ALS). Methods: MUNIX evaluation was performed in three muscles twice on the same day to assess reproducibility. Cut-off values for the MUNIX were based on data from 51 healthy subjects (controls) to evaluate the sensitivity of the technique to detect denervation in 30 subjects with ALS. Results: The method had good reproducibility. The variability was greater in the ALS group. In 23 ALS subjects (77%), low MUNIX values were detected. Most of the muscles with low MUNIX had also low compound muscle action potential (CMAP) and strength, but these parameters were normal in 9% of muscles. According to ROC curve analysis, MUNIX was generally accurate (AUC = 0.9504) for discriminating between healthy individuals and subjects with at least one denervated muscle. Conclusions: MUNIX variability was higher in the ALS group. The method showed good diagnostic performance for the detection of denervation in a sample of patients with ALS. Significance: This study demonstrated that in addition to being a quantitative tool MUNIX can detect denervation in subjects with ALS. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 2979-2984
dc.language.iso eng
dc.publisher Elsevier Ireland Ltd
dc.rights Acesso restrito
dc.subject MUNIX en
dc.subject ALS en
dc.subject MUNE en
dc.subject Reproducibility en
dc.subject Clinical correlation en
dc.subject Denervation en
dc.title MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Med FMUSP, Div Mol Med, Dept Med, BR-05508 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.clinph.2016.06.011
dc.description.source Web of Science
dc.identifier.wos WOS:000381080400003



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account