MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis

MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis

Author Escorcio-Bezerra, Marcio Luiz Autor UNIFESP Google Scholar
Abrahao, Agessandro Autor UNIFESP Google Scholar
de Castro, Isac Google Scholar
Troccoli Chieia, Marco Antonio Autor UNIFESP Google Scholar
de Azevedo, Lyamara Apostolico Autor UNIFESP Google Scholar
Pinheiro, Denise Spinola Autor UNIFESP Google Scholar
de Oliveira Braga, Nadia Iandoli Autor UNIFESP Google Scholar
Bulle de Oliveira, Acary Souza Autor UNIFESP Google Scholar
Manzano, Gilberto Mastrocola Autor UNIFESP Google Scholar
Abstract Objective: To study the reproducibility, diagnostic yield to detect denervation, and clinical correlations of the Motor Unit Number Index (MUNIX) in subjects with Amyotrophic Lateral Sclerosis (ALS). Methods: MUNIX evaluation was performed in three muscles twice on the same day to assess reproducibility. Cut-off values for the MUNIX were based on data from 51 healthy subjects (controls) to evaluate the sensitivity of the technique to detect denervation in 30 subjects with ALS. Results: The method had good reproducibility. The variability was greater in the ALS group. In 23 ALS subjects (77%), low MUNIX values were detected. Most of the muscles with low MUNIX had also low compound muscle action potential (CMAP) and strength, but these parameters were normal in 9% of muscles. According to ROC curve analysis, MUNIX was generally accurate (AUC = 0.9504) for discriminating between healthy individuals and subjects with at least one denervated muscle. Conclusions: MUNIX variability was higher in the ALS group. The method showed good diagnostic performance for the detection of denervation in a sample of patients with ALS. Significance: This study demonstrated that in addition to being a quantitative tool MUNIX can detect denervation in subjects with ALS. (C) 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Keywords MUNIX
ALS
MUNE
Reproducibility
Clinical correlation
Denervation
Language English
Date 2016
Published in Clinical Neurophysiology. Clare, v. 127, n. 9, p. 2979-2984, 2016.
ISSN 1388-2457 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 2979-2984
Origin http://dx.doi.org/10.1016/j.clinph.2016.06.011
Access rights Closed access
Type Article
Web of Science ID WOS:000381080400003
URI http://repositorio.unifesp.br/handle/11600/51123

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