Exposure to high-fat diet since post-weaning induces cardiometabolic damage in adult rats

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dc.contributor.author Fiorino, P.
dc.contributor.author Americo, A. L. V.
dc.contributor.author Muller, C. R.
dc.contributor.author Evangelista, F. S.
dc.contributor.author Santos, F.
dc.contributor.author Leite, A. P. O. [UNIFESP]
dc.contributor.author Farah, V. [UNIFESP]
dc.date.accessioned 2019-07-22T15:46:49Z
dc.date.available 2019-07-22T15:46:49Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.lfs.2016.07.001
dc.identifier.citation Life Sciences. Oxford, v. 160, p. 12-17, 2016.
dc.identifier.issn 0024-3205
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51104
dc.description.abstract Aims: This study sought to investigate the metabolic, hemodynamic and autonomic responses in adult rats exposed to high-fat diet since post-weaning. Main methods: Young male Wistar rats were assigned into groups fed with standard normal diet (3% lipids en
dc.description.abstract ND, n=8) or high-fat diet (30% lipids en
dc.description.abstract HD, n=8) during 8 weeks. Body composition, food intake, serum triglycerides, total cholesterol, insulin, leptin and adiponectin concentrations were determined. Hemodynamic and autonomic evaluations were performed. Renin angiotensin system and nitric oxide were also studied by pharmacological blockades. Key findings: HD group showed no difference in body weight, total cholesterol, food intake in calories and insulin concentration, but visceral fat pads weight, triglycerides and leptin were higher in HD group. Moreover, HD group decreased adiponectin level, increased 12% of mean arterial pressure (MAP) and 6% of heart rate compared with ND group. Spectral analyses showed an increase in cardiovascular sympathetic modulation in HD compared with ND group. Depressor responses after losartan were higher in HD compared with ND group: -9 +/- 0.7 vs.-3 +/- 1.6 mmHg. Pressor responses after L-NAME were higher in HD compared with ND: 45 +/- 8 vs. 32 +/- 5 mmHg. Significance: High-fat diet consumption during early period of life can increase WAT mass and MAP. These alterations may be mediated by an augment in sympathetic activity associated with higher leptin and lower adiponectin levels. These cardiometabolic damages can lead to the development of hypertension and increase cardiovascular risk in adulthood. (C) 2016 Elsevier Inc. All rights reserved. en
dc.description.sponsorship MackPesquisa [059/11]
dc.description.sponsorship Mackenzie PIBIC
dc.format.extent 12-17
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.rights Acesso restrito
dc.subject Obesity en
dc.subject Arterial pressure en
dc.subject Autonomic dysfunction en
dc.subject Adipokines en
dc.subject High-fat diet en
dc.title Exposure to high-fat diet since post-weaning induces cardiometabolic damage in adult rats en
dc.type Artigo
dc.description.affiliation Univ Prebiteriana Mackenzie, Hlth & Biol Sci Ctr, Renal Cardiovasc & Metab Physiopharmacol Lab, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Fac Med, Expt Pathophysiol Dept, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Med, Translat Med Div, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Med, Translat Med Div, Sao Paulo, Brazil
dc.description.sponsorshipID Mack PIBIC:059/11
dc.identifier.doi 10.1016/j.lfs.2016.07.001
dc.description.source Web of Science
dc.identifier.wos WOS:000383520500003


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