Asymptomatic Atherosclerosis in Primary Sjogren Syndrome: Correlation Between Low Ankle Brachial Index and Autoantibodies Positivity

Asymptomatic Atherosclerosis in Primary Sjogren Syndrome: Correlation Between Low Ankle Brachial Index and Autoantibodies Positivity

Author Andreo Garcia, Ana Beatriz Autor UNIFESP Google Scholar
Dardin, Luciana Paula Autor UNIFESP Google Scholar
Minali, Paulo Alexandre Autor UNIFESP Google Scholar
Czapkowsky, Adriano Autor UNIFESP Google Scholar
Ajzen, Sergio Aron Autor UNIFESP Google Scholar
Moca Trevisani, Virginia Fernandes Autor UNIFESP Google Scholar
Abstract Background Primary Sjogren syndrome is a chronic inflammatory autoimmune disease. The delay in diagnosis allows the establishment of a chronic inflammatory state, which makes primary Sjogren syndrome an interesting model for the study of atherosclerosis. Objectives The aim of this study was to evaluate subclinical atherosclerosis in 49 patients with Sjogren syndrome using noninvasive methods. Methods We assessed traditional risk factors such as hypertension, diabetes, dyslipidemia, smoking, and family history of atherosclerosis. Patients with prior cardiovascular events and a history of atherosclerosis were excluded. Clinical and laboratory features were recorded, as well as the European League Against Rheumatism Sjogren's Syndrome Activity Index calculation. The atherosclerosis evaluation was done by carotid intima-media thickness, measured by ultrasonography, and ankle-brachial index (ABI). Results Fifteen patients (31%) had at least 1 traditional risk factor, and 65.3% had a European League Against Rheumatism Sjogren's Syndrome Activity Index score from mild to moderate. Only 2 patients had increased carotid intima-media thickness. However, 59% presented ABI alterations. Multiple correspondence analysis showed a clear correlation between low ABI and the positivity of autoantibodies (antinuclear antibodies, anti-SSA, rheumatoid factor). Conclusions The subgroup of patients with positive autoantibodies showed low ABI, which may represent a higher risk of early atherosclerosis and indicate the need for more careful monitoring in this group.
Keywords ankle-brachial index
atherosclerosis
autoantibodies
carotid ultrasonography
primary Sjogren syndrome
Language English
Date 2016
Published in Jcr-Journal Of Clinical Rheumatology. Philadelphia, v. 22, n. 6, p. 295-298, 2016.
ISSN 1076-1608 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 295-298
Origin http://dx.doi.org/10.1097/RHU.0000000000000413
Access rights Closed access
Type Article
Web of Science ID WOS:000383912900001
URI http://repositorio.unifesp.br/handle/11600/51100

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