Anaplastic Ganglioglioma of the Pineal Region - A Case Report

Anaplastic Ganglioglioma of the Pineal Region - A Case Report

Author Silva da Costa, Marcos Devanir Autor UNIFESP Google Scholar
Centeno, Ricardo Silva Autor UNIFESP Google Scholar
Neto, Mateus Reghin Google Scholar
Doria Netto, Hugo Leonardo Google Scholar
Campos Filho, Jose Maria Google Scholar
Paz, Daniel de Araujo Autor UNIFESP Google Scholar
Rodrigues, Thiago Pereira Autor UNIFESP Google Scholar
Telles, Bruno Augusto Google Scholar
Penteado Lancellotti, Carmen Lucia Google Scholar
Cavalheiro, Sergio Google Scholar
Chaddad-Neto, Feres Autor UNIFESP Google Scholar
Abstract Introduction Gangliogliomas are tumors commonly found in the temporal lobe and related to seizures

their appearance in the pineal region is rarely described. This report characterizes the first case of anaplastic ganglioglioma of the pineal region. Case Report The authors describe the case of a 32-year-old woman that developed progressive headache. AnMRI investigation revealed a pineal tumor. The patient tested negative for biomarkers and underwent surgery through supracerebellar infratentorial approach and achieved gross total resection of the tumor in a challenging location. Pathological analysis revealed a biphasic neoplasm with the following two distinct phenotypes in separate fields: an immature neuronal component with several atypical mitoses and a mature astrocytic component with bipolar cells, microcysts, and eosinophilic bodies. The Ki67/MIB1 proliferation index was 20-30% in localized hotspots. Based on the pathological findings, the tumor was defined as an anaplastic ganglioglioma World Health Organization (WHO) grade III. Discussion/Conclusion Gangliogliomas are classified as glioneural neoplasms based on the histologic findings described as a mixture of neoplastic astrocytes and neurons. Moreover, these tumors represent 0.4-1.3% of tumors of the central nervous system. Authors describe de novo anaplastic ganglioglioma as 1% of the largest series. Gross total resection and adjuvant treatment may play important role in patients' prognostic. In this case, due to the malignant anaplastic component of her tumor, the patient received treatment with temozolamide and radiotherapy after gross total resection of the lesion.
Keywords pineal gland
brain tumor
malignant ganglioglioma
Language English
Date 2016
Published in Brazilian Neurosurgery-Arquivos Brasileiros De Neurocirurgia. Stuttgart, v. 35, n. 3, p. 253-256, 2016.
ISSN 0103-5355 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 253-256
Origin http://dx.doi.org/10.1055/s-0035-1564583
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000392470000014
URI http://repositorio.unifesp.br/handle/11600/51033

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