Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy

Show simple item record

dc.contributor.author Peres, Fernanda F. [UNIFESP]
dc.contributor.author Levin, Raquel [UNIFESP]
dc.contributor.author Almeida, Valeria [UNIFESP]
dc.contributor.author Zuardi, Antonio W.
dc.contributor.author Hallak, Jaime E.
dc.contributor.author Crippa, Jose A.
dc.contributor.author Abilio, Vanessa C. [UNIFESP]
dc.date.accessioned 2019-07-22T15:46:34Z
dc.date.available 2019-07-22T15:46:34Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.3389/fphar.2016.00303
dc.identifier.citation Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
dc.identifier.issn 1663-9812
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/50972
dc.description.abstract Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI) is a paradigm that assesses the sensorimotor gating functioning and is impaired in schizophrenia patients as well as in animal models of this disorder. Recent data point to the participation of the endocannabinoid system in the pathophysiology and pharmacotherapy of schizophrenia. Here, we focus on the effects of cannabinoid drugs on the PPI deficit of animal models of schizophrenia, with greater focus on the SHR (Spontaneously Hypertensive Rats) strain, and on the future prospects resulting from these findings. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP
dc.description.sponsorship Conselho Nacional do Desenvolvimento Cientifico e Tecnologico-CAPES
dc.format.extent -
dc.language.iso eng
dc.publisher Frontiers Media Sa
dc.rights Acesso restrito
dc.subject prepulse inhibition of startle reflex en
dc.subject animal models en
dc.subject schizophrenia en
dc.subject cannabidiol en
dc.subject endocannabinoid system en
dc.subject SHR strain en
dc.title Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy en
dc.type Revisão
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Dept Neurosci & Behav, Ribeirao Preto, Brazil
dc.description.affiliation Natl Inst Translat Med INCT TM, CNPq, Ribeirao Preto, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sao Paulo, Brazil
dc.identifier.doi 10.3389/fphar.2016.00303
dc.description.source Web of Science
dc.identifier.wos WOS:000382714800001



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account