Mesenchymal stem cells and chronic renal artery stenosis

Show simple item record Oliveira-Sales, Elizabeth B. [UNIFESP] Boim, Mirian A. [UNIFESP] 2019-01-21T10:30:19Z 2019-01-21T10:30:19Z 2016
dc.identifier.citation American Journal Of Physiology-Renal Physiology. Bethesda, v. 310, n. 1, p. F6-F9, 2016.
dc.identifier.issn 1931-857X
dc.description.abstract Renal artery stenosis is the main cause of renovascular hypertension and results in ischemic nephropathy characterized by inflammation, oxidative stress, microvascular loss, and fibrosis with consequent functional failure. Considering the limited number of strategies that effectively control renovascular hypertension and restore renal function, we propose that cell therapy may be a promising option based on the regenerative and immunosuppressive properties of stem cells. This review addresses the effects of mesenchymal stem cells (MSC) in an experimental animal model of renovascular hypertension known as 2 kidney-1 clip (2K-1C). Significant benefits of MSC treatment have been observed on blood pressure and renal structure of the stenotic kidney. The mechanisms involved are discussed. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação Oswaldo Ramos (FOR)
dc.format.extent F6-F9
dc.language.iso eng
dc.publisher Amer Physiological Soc
dc.relation.ispartof American Journal Of Physiology-Renal Physiology
dc.rights Acesso aberto
dc.subject renal sympathetic nerve en
dc.subject renin-angiotensin system en
dc.subject renovascular hypertension en
dc.subject cell therapy en
dc.subject renal ischemiaExperimental Renovascular Disease en
dc.subject Endothelial Progenitor Cells en
dc.subject Angiotensin-Ii en
dc.subject Oxidative Stress en
dc.subject Nervous-System en
dc.subject Rat Model en
dc.subject Hypertension en
dc.subject Injury en
dc.subject Mechanisms en
dc.subject Senescence en
dc.title Mesenchymal stem cells and chronic renal artery stenosis en
dc.type Revisão
dc.description.affiliation Univ Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Div Renal, Rua Pedro de Toledo 781, Sao Paulo, Brazil.
dc.identifier.doi 10.1152/ajprenal.00341.2015
dc.description.source Web of Science
dc.identifier.wos WOS:000366593500002


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