Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

Author Assis, L. Autor UNIFESP Google Scholar
Milares, L. P. Autor UNIFESP Google Scholar
Almeida, T. Google Scholar
Tim, C. Google Scholar
Magri, A. Autor UNIFESP Google Scholar
Fernandes, K. R. Autor UNIFESP Google Scholar
Medalha, C Autor UNIFESP Google Scholar
Renno, A. C. Muniz Autor UNIFESP Google Scholar
Abstract Objective: The aim of this study was to evaluate the effects of an aerobic exercise training and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Material and methods: Fifty male Wistar rats were randomly divided into five groups: control group (CG)

knee OA control group (OAC)

OA plus exercise training group (OAT)

OA plus LLLT group (OAL)

OA plus exercise training associated with LLLT group (OATL). The exercise training (treadmill

16 m/min

50 min/day) and the laser irradiation (two points-medial and lateral side of the left joint

24 sessions) started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results showed that all treated groups showed (irradiated or not) a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and chondrocytes organization, a lower degenerative process measured by OARSI score and higher thickness values. Additionally, all treated group showed a reduced expression in IL-1 beta, caspase-3 and MMP-13 compared to OAC. Moreover, a lower caspase-3 expression was observed in OATL compared to OAL and OAT. Conclusion: These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Keywords Low-level laser therapy
Articular cartilage
Knee osteoarthritis
RehabilitationCartilage Matrix Degradation
Biomechanical Signals
Oxidative Stress
Controlled-Trial
Joint
Expression
Protocol
Pain
Apoptosis
Rabbit
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2012-20145-0
Date 2016
Published in Osteoarthritis And Cartilage. Oxford, v. 24, n. 1, p. 169-177, 2016.
ISSN 1063-4584 (Sherpa/Romeo, impact factor)
Publisher Elsevier Sci Ltd
Extent 169-177
Origin http://dx.doi.org/10.1016/j.joca.2015.07.020
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000366839100020
URI http://repositorio.unifesp.br/handle/11600/49696

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