Purple carrot extract protects against cadmium intoxication in multiple organs of rats: Genotoxicity, oxidative stress and tissue morphology analyses

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dc.contributor.author Claudio, Samuel Range| [UNIFESP]|Boiago Gollucke, Andrea Pittelli [UNIFESP]
dc.contributor.author Yamamura, Hirochi [UNIFESP]
dc.contributor.author Morais, Damila Rodrigues
dc.contributor.author Bataglion, Giovana Anceski
dc.contributor.author Eberlin, Marcos Nogueira
dc.contributor.author Peres, Rogerio Correa [UNIFESP]
dc.contributor.author Fujiyama Oshima, Celina Tizuko [UNIFESP]
dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.date.accessioned 2019-01-21T10:30:18Z
dc.date.available 2019-01-21T10:30:18Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.jtemb.2015.08.006
dc.identifier.citation Journal Of Trace Elements In Medicine And Biology. Jena, v. 33, p. 37-47, 2016.
dc.identifier.issn 0946-672X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49691
dc.description.abstract The aim of this study was to investigate if purple carrot extract is able to protect against the noxious activities induced by cadmium exposure in multiple organs of rats. For this purpose, histopathological analysis, genotoxicity and oxidative status were investigated in this setting. A total of twenty Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into four groups (n=5), as follows: Control group (non-treated group, CTRL) en
dc.description.abstract Cadmium group (Cd) and Purple carrot extract groups at 400 mg/L or 800 mg/L. Histopathological analysis revealed that liver from animals treated with purple carrot extract improved tissue degeneration induced by cadmium intoxication. Genetic damage was reduced in blood and hepatocytes as depicted by comet and micronucleus assays in animals treated with purple carrot extract. SOD-CuZn and cytocrome C gene expression increased in groups treated with purple carrot extract. Purple carrot extract also reduced the 80HdG levels in liver cells when compared to cadmium group. Taken together, our results demonstrate that purple carrot extract is able to protect against cadmium intoxication by means of reducing tissue regeneration, genotoxicity and oxidative stress in multiple organs of Wistar rats. (C) 2015 Elsevier GmbH. All rights reserved. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 37-47
dc.language.iso eng
dc.publisher Elsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartof Journal Of Trace Elements In Medicine And Biology
dc.rights Acesso restrito
dc.subject Purple carrot en
dc.subject Cadmium en
dc.subject Rat en
dc.subject Genotoxicity en
dc.subject Oxidative stressGrape Juice Concentrate en
dc.subject Dna-Damage en
dc.subject Cytochrome-C en
dc.subject Wistar Rats en
dc.subject Blood-Cells en
dc.subject In-Vivo en
dc.subject Liver en
dc.subject Anthocyanins en
dc.subject Apoptosis en
dc.subject Exposure en
dc.title Purple carrot extract protects against cadmium intoxication in multiple organs of rats: Genotoxicity, oxidative stress and tissue morphology analyses en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, UNIFESP, Dept Biosciences, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Campinas UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, Campinas, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, UNIFESP, Paulista Med Sch, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Biociencias, Ave Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifesp Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP, SP, Brazil
dc.identifier.doi 10.1016/j.jtemb.2015.08.006
dc.description.source Web of Science
dc.identifier.wos WOS:000367110100007



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