Evaluation of a modified pamidronate protocol for the treatment of osteogenesis imperfecta

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dc.contributor.author Palomo, Telma [UNIFESP]
dc.contributor.author Andrade, Maria C. [UNIFESP]
dc.contributor.author Peters, Barbara S. E.
dc.contributor.author Reis, Fernanda A. [UNIFESP]
dc.contributor.author Carvalhaes, Joao Tomas A. [UNIFESP]
dc.contributor.author Glorieux, Francis H.
dc.contributor.author Rauch, Frank
dc.contributor.author Lazaretti-Castro, Marise [UNIFESP]
dc.date.accessioned 2019-01-21T10:30:15Z
dc.date.available 2019-01-21T10:30:15Z
dc.date.issued 2016
dc.identifier https://doi.org/10.1007/s00223-015-0061-y
dc.identifier.citation Calcified Tissue International. New york, v. 98, n. 1, p. 42-48, 2016.
dc.identifier.issn 0171-967X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49652
dc.description.abstract Intravenous pamidronate is widely used to treat children with osteogenesis imperfecta (OI). In a well-studied protocol ('standard protocol'), pamidronate is given at a daily dose of 1 mg per kg body weight over 4 h on 3 successive days en
dc.description.abstract infusion cycles are repeated every 4 months. Here, we evaluated renal safety of a simpler protocol for intravenous pamidronate infusions (2 mg per kg body weight given in a single infusion over 2 h, repeated every 4 months en
dc.description.abstract 'modified protocol'). Results of 18 patients with OI types I, III, or IV treated with the modified protocol for 12 months were compared to 18 historic controls, treated with standard protocol. In the modified protocol, mild transient post-infusion increases in serum creatinine were found during each infusion but after 12 months serum creatinine remained similar from baseline [0.40 mg/dl (SD: 0.13)] to the end of the study [0.41 mg/dl (SD: 0.11)] (P = 0.79). The two protocols led to similar changes in serum creatinine during the first pamidronate infusion [modified protocol: +2 % (SD: 21 %) en
dc.description.abstract standard protocol: -3 % (SD: 8 %) en
dc.description.abstract P = 0.32]. Areal lumbar spine bone mineral density Z-scores increased from -2.7 (SD: 1.5) to -1.8 (SD: 1.4) with the modified protocol, and from -4.1 (SD: 1.4) to -3.1 (SD: 1.1) with standard protocol (P = 0.68 for group differences in bone density Z-score changes). The modified pamidronate protocol is safe and may have similar effects on bone density as the standard pamidronate protocol. More studies are needed with longer follow-up to prove anti-fracture efficacy. en
dc.description.sponsorship Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES)
dc.format.extent 42-48
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Calcified Tissue International
dc.rights Acesso restrito
dc.subject Pamidronate en
dc.subject Safety en
dc.subject Renal Function en
dc.subject Osteogenesis Imperfecta en
dc.subject EfficacyMultiple-Myeloma en
dc.subject Zoledronic Acid en
dc.subject Renal Safety en
dc.subject Intravenous Pamidronate en
dc.subject Clinical-Trials en
dc.subject Breast-Cancer en
dc.subject Children en
dc.subject Bone en
dc.subject Bisphosphonates en
dc.subject Osteoporosis en
dc.title Evaluation of a modified pamidronate protocol for the treatment of osteogenesis imperfecta en
dc.type Artigo
dc.description.affiliation Bone and Mineral Unit, Division of Endocrinology Universidade Federal de São Paulo, São Paulo Brazil
dc.description.affiliation Department of Pediatric Nephrology. Universidade Federal de São Paulo. São Paulo, Brazil
dc.description.affiliation Department of Nutrition. Public Health School, USP. São Paulo, Brazil
dc.description.affiliation Department of Radiology. Universidade Federal de São Paulo. São Paulo, Brazil
dc.description.affiliation Shriners Hospital for Children. Montreal, Canada
dc.description.affiliationUnifesp Bone and Mineral Unit, Division of Endocrinology Universidade Federal de São Paulo, São Paulo Brazil
dc.description.affiliationUnifesp Department of Pediatric Nephrology. Universidade Federal de São Paulo. São Paulo, Brazil
dc.description.affiliationUnifesp Department of Radiology. Universidade Federal de São Paulo. São Paulo, Brazil
dc.identifier.doi 10.1007/s00223-015-0061-y
dc.description.source Web of Science
dc.identifier.wos WOS:000368103500004



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