Risk factors for recurrent wheezing - international study of wheezing in infants (eisl) phase 3

Risk factors for recurrent wheezing - international study of wheezing in infants (eisl) phase 3

Author Aranda, Carolina Sanchez Autor UNIFESP Google Scholar
Wandalsen, Gustavo Falbo Autor UNIFESP Google Scholar
Fonzar, Ligia Furtado Autor UNIFESP Google Scholar
Dela Bianca, Ana Caroline Cavalcanti Google Scholar
Mallol, Javier Google Scholar
Solé, Dirceu Autor UNIFESP Google Scholar
Abstract Background: We aimed to identify factors associated with recurrent wheezing (RW) in infants in the first year of life living in the Southern region of Sao Paulo city and participating in the "Estudio Internacional de Sibilancias en Lactantes (EISL)" - phase 3 (P3). Methods: 1335 parents of infants who were attended in primary care health units in the Southern region of Sao Paulo city from 2009 to 2010 answered the EISL-P3 written questionnaire. The wheezing group was stratified in accordance to the frequency of wheezing episodes as occasional wheezing (OW, less than three episodes), or RW (three or more episodes). Wheezing-associated factors were evaluated using multivariate analysis and were expressed as odds ratio (OR) and 95% confidence interval (95%CI). Results: The most relevant factors related to OW were pneumonia (OR = 3.10, 95%CI=1.68-5.73), hospitalisation due to pneumonia (OR = 2.88, 95%CI = 1.26-6.56) and recurrent upper respiratory infection (URI, OR = 1.87, 95%CI = 1.25-2.81). Regarding RW, recurrent URI (OR = 5.34, 95%CI = 3.83-7.45), pneumonia (OR= 4.06, 95%CI = 2.87-5.74) and asthmatic siblings (OR= 3.02, 95%CI = 1.67-5.45) were the most significantly associated factors. Conclusions: In the present study, we found that recurrent URI, positive history of pneumonia and familiar history of asthma were the most relevant factors associated with RW. The precocious knowledge of these factors can enable the identification of the probable asthmatic infants and can improve both prevention strategies and treatment of these patients. (C) 2014 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
Keywords Asthma
Respiratory Sounds
Respiratory Tract Infections
Risk Factors1st Year
Childhood Asthma
Language English
Date 2016
Published in Allergologia Et Immunopathologia. Barcelona, v. 44, n. 1, p. 3-8, 2016.
ISSN 0301-0546 (Sherpa/Romeo, impact factor)
Publisher Elsevier doyma sl
Extent 3-8
Origin http://dx.doi.org/10.1016/j.aller.2015.05.011
Access rights Closed access
Type Article
Web of Science ID WOS:000369047300002
URI http://repositorio.unifesp.br/handle/11600/49636

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