Hair cortisol in drug-naive first-episode individuals with psychosis

Hair cortisol in drug-naive first-episode individuals with psychosis

Author Andrade, Elvis H. Autor UNIFESP Google Scholar
Rizzo, Lucas B. Autor UNIFESP Google Scholar
Noto, Cristiano Autor UNIFESP Google Scholar
Ota, Vanessa K. Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Daruy-Filho, Ledo Google Scholar
Tasso, Brazilio de C. Google Scholar
Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Cordeiro, Quirino Google Scholar
Belangero, Sintia I. Autor UNIFESP Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Objectives: To compare hair cortisol concentrations (HCC) in drug-na ve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology. Methods: Twenty-four drug-na ve FEP patients and 27 gender- and age-matched healthy control subjects were recruited. The Structured Clinical Interview for DSM-IV (SCID-1) was used to confirm/rule out diagnoses, and the Positive and Negative Symptoms Scale (PANSS) was used to assess symptom severity. Hair samples (2-3 cm long) obtained from the posterior vertex region of the scalp were processed in 1-cm segments considering a hair growth rate of 1 cm per month. The 1-cm segments were classified according to their proximity to the scalp: segment A was the closest to the scalp and referred to the month prior to inclusion in the study. Segments B and C referred to the 2nd and 3rd months prior to the time of evaluation respectively. Hair steroid extraction was performed using a known protocol. Results: Two-way analysis of covariance (ANCOVA) with gender and age as covariates revealed a group effect (F-1 106 = 4.899, p = 0.029) on HCC. Between-segment differences correlated with total PANSS score and with PANSS General Psychopathology subscale and total score. Conclusions: Our findings suggest that hypothalamic-pituitary-adrenal (HPA) axis, as assessed by long-term (3-month) cortisol concentration, is abnormal in the early stages of psychosis. The magnitude of changes in HCC over time prior to the FEP correlates to psychopathology. HPA axis abnormalities might begin prior to full-blown clinical presentation requiring hospital admission.
Keywords First-Episode Psychosis
Schizophrenia
Cortisol
StressPituitary-Adrenal Axis
1st Episode Psychosis
Awakening Response
Dehydroepiandrosterone-Sulfate
Atypical Antipsychotics
Glucose-Tolerance
Schizophrenia
Stress
Depression
Secretion
Language English
Sponsor Fundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP) [11/23918-8]
Grant number This study was funded by Fundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP
grant 11/23918-8).
Date 2016
Published in Revista Brasileira De Psiquiatria. Sao paulo, v. 38, n. 1, p. 11-16, 2016.
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Assoc brasileira psiquiatria
Extent 11-16
Origin http://dx.doi.org/10.1590/1516-4446-2014-1634
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000372944900003
SciELO ID S1516-44462016000100011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/49564

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