Depression in Parkinson's disease: clinical-epidemiological correlates and comparison with a controlled group of non-parkinsonian geriatric patients

Depression in Parkinson's disease: clinical-epidemiological correlates and comparison with a controlled group of non-parkinsonian geriatric patients

Alternative title Depressão na doença de Parkinson: análise clínico-epidemiológica e comparação com um grupo de pacientes geriátricos não parkinsonianos
Author Veiga, Beatriz Azevedo dos Anjos Godke Autor UNIFESP Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Silva, Sonia Maria César de Azevedo Autor UNIFESP Google Scholar
Goulart, Fabrício de Oliveira Autor UNIFESP Google Scholar
Cendoroglo, Maysa Seabra Autor UNIFESP Google Scholar
Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: To evaluate and compare the frequency and severity of major depression in patients with Parkinson's disease and in individuals older than 60 years without neurological, rheumatological and/or oncological comorbidities. METHOD: We studied 50 patients with Parkinson's disease older than 60 years and 50 geriatric patients. Subjects with scores of Mini Mental State Examination indicating cognitive impairment were excluded. We used Diagnostic Statistical Manual of Mental Diseases-IV criteria to diagnose major depression and the Hamilton Depression Scale and the Beck Depression Inventory to rate it. The Unified Parkinson's Disease Rating Scale part 3 and the Hoehn and Yahr Scale were used to evaluate the motor severity of Parkinson's disease. RESULTS: Major depression was found in 42% of Parkinson's disease patients and in 10% of the geriatric patients (p < 0.001). The scores of the Hamilton Depression Scale and the Beck Depression Inventory were higher in Parkinson's disease patients (p < 0.001). Depressed Parkinson's disease patients had longer duration of Parkinson's disease (p = 0.020) and higher scores on the Unified Parkinson's Disease Rating Scale part 3 (p = 0.029) and the Yahr Scale (p = 0.027). CONCLUSIONS: The frequency (42%) and severity of major depression were higher in Parkinson's disease patients. Longer duration of Parkinson's disease, higher scores on the Unified Parkinson's Disease Rating Scale part 3 and the Hoehn and Yahr Scale were significantly associated with major depression.

RESUMO OBJETIVO: Avaliar e comparar a freqüência e intensidade de depressão em um grupo com doença de Parkinson e um grupo sem doença de Parkinson, sem doença neurológica, reumatológica e/ou oncológica acompanhados na Universidade Federal de São Paulo (UNIFESP). MÉTODO: Avaliaram-se 50 indivíduos com doença de Parkinson (grupo Parkinson) e 50 indivíduos sem doença de Parkinson (grupo controle) acima de 60 anos. Excluíram-se indivíduos que demonstravam alterações cognitivas pelo Mini Exame Estado Mental. Todos foram submetidos à entrevista estruturada para depressão maior do Diagnostic Statistical Manual of Mental Diseases-IV, Escala de Depressão de Hamilton e Inventário de Depressão de Beck. O grupo Parkinson foi submetido à avaliação física por Unified Parkinson Disease Rating Scale 3 e Hoehn-Yahr. RESULTADOS: 42% do grupo Parkinson e 10% do grupo controle (p < 0,001) apresentaram depressão maior, segundo os critérios do Diagnostic Statistical Manual of Mental Diseases-IV. As médias de pontuação da Escala de Depressão de Hamilton e do Inventário de Depressão de Beck foram maiores no grupo Parkinson (p < 0,001). Em tempo de doença (p = 0,020), as médias dos escores de Hoehn-Yahr (p = 0,027) e Unified Parkinson Disease Rating Scale 3 (p = 0,029) foram maiores nos parkinsonianos com depressão. CONCLUSÕES: A freqüência (42%) e a intensidade de depressão maior foram maiores no grupo Parkinson. A depressão maior também esteve significativamente relacionada à pior função motora dos parkinsonianos.
Keywords Parkinson's disease
Depression
Prevalence
Patient selection
Geriatrics
Doença de Parkinson
Depressão
Prevalência
Seleção de pacientes
Geriatria
Language English
Date 2009-03-01
Published in VEIGA, Beatriz Azevedo dos Anjos Godke et al . Depression in Parkinson's disease: clinical-epidemiological correlates and comparison with a controlled group of non-parkinsonian geriatric patients. Rev. Bras. Psiquiatr., São Paulo , v. 31, n. 1, p. 39-42, mar. 2009
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Psiquiatria - ABP
Extent 39-42
Origin http://dx.doi.org/10.1590/S1516-44462009000100010
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000268348400010
SciELO ID S1516-44462009000100010 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/4954

Show full item record




File

Name: S1516-44462009000100010.pdf
Size: 228.9Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account