Th17 cells and cd4(+) multifunctional t cells in patients with systemic lupus erythematosus

Th17 cells and cd4(+) multifunctional t cells in patients with systemic lupus erythematosus

Title: Th17 cells and cd4(+) multifunctional t cells in patients with systemic lupus erythematosus;
Linfócitos Th17 e linfócitos T CD4+ multifuncionais em pacientes com lúpus eritematoso sistêmico
Author Pereira Araujo, Julio Antonio Autor UNIFESP Google Scholar
Mesquita, Danilo, Jr. Autor UNIFESP Google Scholar
Cruvinel, Wilson de Melo Autor UNIFESP Google Scholar
Salmazi, Karina Inacio Google Scholar
Kallas, Esper Georges Google Scholar
Coelho Andrade, Luis Eduardo Autor UNIFESP Google Scholar
Abstract Introduction/Objective: Recent evidence suggests that abnormalities involving Th17 lymphocytes are associated with the pathophysiology of systemic lupus erythematosus (SLE). In addition, multifunctional T cells (MFT), i.e., those producing multiple cytokines simultaneously, are present in the inflammatory milieu and may be implicated in the autoimmune process observed in SLE. In the present study, we aimed to characterize the functional status of CD4(+) T cells in SLE by simultaneously determining the concentration of IL-2, IFN-gamma and IL-17 in lymphocyte cultures under exogenous and self-antigenic stimuli. Patients and methods: Eighteen patients with active disease, 18 with inactive disease, and 14 healthy controls had functional status of CD4(+) T cells analyzed. Results: We found that SLE patients presented a decreased number of total CD4(+) cells, an increased number of activated T cells, and an increased frequency of Th17 cells compared to healthy controls (HC). MFT cells had increased frequency in SLE patients and there was an increased frequency of tri-functional MFT in patients with active SLE compared with those with inactive SLE. Interestingly, MTF cells produced larger amounts of IFN gamma than mono-functional T cells in patients and controls. Conclusion: Taken together these data indicate the participation of recently activated Th17 cells and MTF cells in the SLE pathophysiology. (C) 2015 Elsevier Editora Ltda. All rights reserved.
Keywords Systemic Lupus Erythematosus
T Lymphocytes
Multifunctional T CellsDisease-Activity
Language Portuguese
Date 2016
Published in Revista Brasileira De Reumatologia. New york, v. 56, n. 1, p. 28-36, 2016.
ISSN 0482-5004 (Sherpa/Romeo, impact factor)
Publisher Elsevier science inc
Extent 28-36
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000374895300006
SciELO ID S0482-50042016000100028 (statistics in SciELO)

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