International consensus on ana patterns (icap): the bumpy road towards a consensus on reporting ana results

International consensus on ana patterns (icap): the bumpy road towards a consensus on reporting ana results

Author Damoiseaux, Jan Google Scholar
von Muhlen, Carlos A. Google Scholar
Garcia-De La Torre, Ignacio Google Scholar
Gabriel Carballo, Orlando Google Scholar
Cruvinel, Wilson de Melo Google Scholar
Carvalho Francescantonio, Paulo Luiz Google Scholar
Fritzler, Marvin J. Google Scholar
Herold, Manfred Google Scholar
Mimori, Tsuneyo Google Scholar
Satoh, Minoru Google Scholar
Andrade, Luis E. C. Autor UNIFESP Google Scholar
Chan, Edward K. L. Google Scholar
Conrad, Karsten Google Scholar
Abstract The International Consensus on ANA Patterns (ICAP) was initiated as a workshop aiming to thoroughly discuss and achieve consensus regarding the morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells. One of the topics discussed at the second ICAP workshop, and addressed in this paper, was the harmonization of reporting ANA test results. This discussion centered on the issue if cytoplasmic and mitotic patterns should be reported as positive or negative. This report outlines the issues that impact on two major different reporting methods. Although it was appreciated by all participants that cytoplasmic and mitotic patterns are clinically relevant, implications for existing diagnostic/classification criteria for ANA-associated diseases in particular hampered a final consensus on this topic. Evidently, a more concerted action of all relevant stake-holders is required. Future ICAP workshops may help to facilitate this action.
Keywords Anti-Nuclear Antibodies
Indirect Immunofluorescence
Nuclear Patterns
Cytoplasmic Patterns
Mitotic Patterns
HarmonizationSystemic-Lupus-Erythematosus
Indirect Immunofluorescence
Classification Criteria
Antinuclear Antibodies
Autoimmune Hepatitis
American-College
Hep-2 Cells
Recommendations
Autoantibodies
Guidelines
Language English
Date 2016
Published in Autoimmunity Highlights. Milan, v. 7, n. 1, 2016.
ISSN 2038-0305 (Sherpa/Romeo, impact factor)
Publisher Springer-verlag italia srl
Origin https://doi.org/10.1007/s13317-016-0075-0
Access rights Open access Open Access
Type Revisão
Web of Science ID WOS:000375693500001
URI http://repositorio.unifesp.br/handle/11600/49513

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