A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy

A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy

Author Janovsky, Carolina Castro Porto Silva Autor UNIFESP Google Scholar
Maciel, Rui M. B. Autor UNIFESP Google Scholar
Camacho, Cleber P. Autor UNIFESP Google Scholar
Padovani, Rosalia P. Autor UNIFESP Google Scholar
Nakabashi, Claudia C. Autor UNIFESP Google Scholar
Yang, Ji H. Autor UNIFESP Google Scholar
Malouf, Eduardo Z. Autor UNIFESP Google Scholar
Ikejiri, Elza S. Autor UNIFESP Google Scholar
Mamone, M. Conceicao O. C. Autor UNIFESP Google Scholar
Wagner, Jairo Google Scholar
Andreoni, Danielle M. Autor UNIFESP Google Scholar
Biscolla, Rosa Paula M. Autor UNIFESP Google Scholar
Abstract Objectives: To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). Study Design: We prospectively followed up 57 patients

3 months after TT, thyroglobulin (Tg) assessment and neck ultrasonography (US) were performed while patients were taking L-T-4, presenting suppressed TSH. Six months after TT, patients underwent stimulated Tg testing and whole-body scan (WBS) after recombinant TSH (rhTSH). Then, 18 months after TT, the patients were evaluated by neck US and Tg under TSH between 0.5 and 2.0 mIU/ml. Two years after TT, we performed another rhTSH assessment, measuring Tg and making a WBS. The patients were then annually monitored with neck US and Tg measurement under TSH between 0.5 and 2.0 mIU/l for 36-84 months. Results: Neck US of all patients, 3 months after TT, presented no evidence of abnormal residual tissues or metastatic lymph nodes (negative neck US)

at this time, the mean Tg level was 0.42 ng/ml. Six months after surgery, after rhTSH, the mean thyroid bed uptake was 1.82%, and Tg levels ranged from 0.10 to 22.30 ng/ml (mean, 2.89 ng/ml). The patients were followed up without any sign of recurrence (negative neck US and stable or decreasing Tg levels). During the ongoing follow-up, the Tg trend was stable or decreasing, independently of the initial suppressed or stimulated Tg level, or WBS uptake. Conclusions: In patients with low-risk differentiated thyroid cancer, who were operated by TT and who did not undergo RRA, an excellent response to treatment may be confirmed by annual neck US and Tg trend. (C) 2015 European Thyroid Association Published by S. Karger AG, Basel
Keywords Low-Risk Thyroid Carcinoma
Thyroglobulin
Thyroglobulin Temporal Trend
Radioiodine Remnant Ablation
Neck UltrasoundLong-Term Impact
Radioactive Iodine
Increasing Incidence
Therapy
Papillary
Association
Surveillance
Recurrence
Adjuvant
Update
Language English
Sponsor Brazilian Ministry of Health [25000.168513/2008-11]
Grant number Brazilian Ministry of Health: 25000.168513/2008-11
Date 2016
Published in European Thyroid Journal. Basel, v. 5, n. 1, p. 44-49, 2016.
ISSN 2235-0640 (Sherpa/Romeo, impact factor)
Publisher Future Sci Ltd
Extent 44-49
Origin https://doi.org/10.1159/000442048
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000381685300007
URI http://repositorio.unifesp.br/handle/11600/49445

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