Second-generation central venous catheter in the prevention of bloodstream infection: a systematic review

Second-generation central venous catheter in the prevention of bloodstream infection: a systematic review

Author Dorociaki Stocco, Janislei Gislei Google Scholar
Hoers, Hellen Google Scholar
Pott, Franciele Soares Google Scholar
Crozeta, Karla Google Scholar
Barbosa, Dulce Aparecida Autor UNIFESP Google Scholar
Meier, Marineli Joaquim Google Scholar
Abstract Objective: to evaluate the effectiveness and safety in the use of second-generation central venous catheters impregnated in clorhexidine and silver sulfadiazine when compared with other catheters, being them impregnated or not, in order to prevent the bloodstream infection prevention. Method: systematic review with meta-analysis. Databases searched: MEDLINE, EMBASE, CINAHL, LILACS/SciELO, Cochrane CENTRAL

search in Congress Proceedings and records from Clinical Trials. Results: 1.235 studies were identified, 97 were pre-selected and 4 were included. In catheter-related bloodstream infection, there was no statistical significance between second-generation impregnated catheter compared with the non-impregnated ones, absolute relative risk 1,5% confidence interval 95% (3%-1%), relative risk 0,68 (confidence interval 95%, 0,40-1,15) and number needed to treat 66. In the sensitivity analysis, there was less bloodstream infection in impregnated catheters (relative risk 0,50, confidence interval 95%, 0,26-0,96). Lower colonization, absolute relative risk 9,6% (confidence interval 95%, 10% to 4%), relative risk 0,51 (confidence interval 95% from 0,38-0,85) and number needed to treat 5. Conclusion: the use of second-generation catheters was effective in reducing the catheter colonization and infection when a sensitivity analysis is performed. Future clinical trials are suggested to evaluate sepsis rates, mortality and adverse effects.
Keywords Catheterization, Central Venous
Catheter-Related Infection
Colonization
Sepsis
Meta-AnalysisSilver-Sulfadiazine
Controlled-Trial
Chlorhexidine
Guidelines
Hospitals
Language English
Date 2016
Published in Revista Latino-Americana De Enfermagem. Ribeirao preto, v. 24, p. e2722, 2016.
ISSN 1518-8345 (Sherpa/Romeo, impact factor)
Publisher Soc Brasil Pediatria
Extent e2722
Origin http://dx.doi.org/10.1590/1518-8345.0756.2722
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000380887900028
SciELO ID S0104-11692016000100605 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/49428

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