A case-control study on the oxidative balance of 50% autologous serum eye drops

A case-control study on the oxidative balance of 50% autologous serum eye drops

Author Gus, Patricia Ioschpe Autor UNIFESP Google Scholar
Marinho, Diane Google Scholar
Zelanis, Samira Google Scholar
Bello-Klein, Adriane Google Scholar
Locatelli, Claudete Google Scholar
Nicola, Felipe Google Scholar
Kunzler, Ana Laura Google Scholar
Gatelli Fernandes, Tania Regina Google Scholar
Carraro, Cristina Campos Google Scholar
Barbosa, Luciene Autor UNIFESP Google Scholar
Abstract Importance. Autologous serum (AS) eye drops are recommended for severe dry eye in patients with ocular surface disease. No description of the antioxidant balance of AS eye drops has been reported in the literature. Objective. This study sought to evaluate the total reactive antioxidant potential (TRAP) and concentration of reactive oxygen species (ROS) in samples of 50% AS eye drops and their correlations with the demographic characteristics and lifestyle habits of patients with ocular surface disease and healthy controls. Design. This was a case-control study with a 3-month follow-up period. Participants. 16 patients with severe dry eye disease of different etiologies and 17 healthy controls matched by age, gender, and race were included. Results. TRAP and ROS were detected at all evaluated times. There were no differences in the mean ROS (p = 0.429) or TRAP (p = 0.475) levels between cases and controls. No statistically significant differences in the concentrations of ROS or TRAPs were found at 0, 15, or 30 days (p for ROS = 0.087 and p for TRAP = 0.93). Neither the demographic characteristics nor the lifestyle habits were correlated with the oxidative balance of the 50% AS eye drops. Conclusions and Relevance. Both fresh and frozen 50% AS eye drops present antioxidant capacities and ROS in an apparently stable balance. Moreover, patients with ocular surface disease and normal controls produce equivalent AS eye drops in terms of oxidative properties.
Keywords Dry Eye
Iodide Iontophoresis
Stress
Disease
Eyedrops
Language English
Sponsor Fund for Research and Event Promotion (FIPE) of Hospital de Clinicas de Porto Alegre (HCPA) [14-0304]
Grant number FIPE: Project no. 14-0304
Date 2016
Published in Oxidative Medicine And Cellular Longevity. London, 2016.
ISSN 1942-0900 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
Origin http://dx.doi.org/10.1155/2016/9780193
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000382640900001
URI http://repositorio.unifesp.br/handle/11600/49424

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