Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: a comparison with ebselen

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dc.contributor.author Petronilho, Fabricia
dc.contributor.author Michels, Monique
dc.contributor.author Danielski, Lucineia G.
dc.contributor.author Goldim, Mariana Pereira
dc.contributor.author Florentino, Drielly
dc.contributor.author Vieira, Andriele
dc.contributor.author Mendonca, Mariana G.
dc.contributor.author Tournier, Moema
dc.contributor.author Piacentini, Barbara
dc.contributor.author Della Giustina, Amanda
dc.contributor.author Leffa, Daniela D.
dc.contributor.author Pereira, Gregorio W. [UNIFESP]
dc.contributor.author Pereira, Volnei D.
dc.contributor.author Teixeira Da Rocha, Joao Batista
dc.date.accessioned 2019-01-21T10:29:48Z
dc.date.available 2019-01-21T10:29:48Z
dc.date.issued 2016
dc.identifier https://doi.org/10.1016/j.prp.2016.04.012
dc.identifier.citation Pathology Research And Practice. Jena, v. 212, n. 9, p. 755-760, 2016.
dc.identifier.issn 0344-0338
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49400
dc.description.abstract Objetive: The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)(2) and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods: The effects of (PhSe)(2) and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results: Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)(2) improved this response. Moreover, the treatment with (PhSe)(2) decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. LB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions: The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)(2) more effective than EB. (C) 2016 Elsevier GmbH. All rights reserved. en
dc.format.extent 755-760
dc.language.iso eng
dc.publisher Funpec-Editora
dc.relation.ispartof Pathology Research And Practice
dc.rights Acesso restrito
dc.subject Diphenyl Diselenide en
dc.subject Dss Induced-Colitis en
dc.subject Ebselen en
dc.subject Oxidative Stress en
dc.subject Ulcerative ColitisDextran Sulfate Sodium en
dc.subject Lipid-Peroxidation en
dc.subject Bowel-Disease en
dc.subject Animal-Models en
dc.subject Rats en
dc.subject Metabolism en
dc.subject Selenium en
dc.subject Injury en
dc.subject Damage en
dc.title Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: a comparison with ebselen en
dc.type Artigo
dc.description.affiliation Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil
dc.description.affiliation Clinical and Experimental Pathophysiology Laboratory, Graduate Program in Health Sciences, University of South Santa Catarina, Tubarão, SC, Brazil
dc.description.affiliation Laboratory of Molecular and Cellular Biology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil
dc.description.affiliation Department of Pathology, Federal University of São Paulo, Sao Paulo, SP, Brazil
dc.description.affiliation Institute of Pathological Anatomy and Histopathology DI-PREVER, Tubarão, SC, Brazil
dc.description.affiliation Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, RS, Brazil
dc.description.affiliationUnifesp Department of Pathology, Federal University of São Paulo, Sao Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.prp.2016.04.012
dc.description.source Web of Science
dc.identifier.wos WOS:000383523500001



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