Ocular biocompatibility of poly-n-isopropylacrylamide (pnipam)

Ocular biocompatibility of poly-n-isopropylacrylamide (pnipam)

Author Lima, Luiz H. Autor UNIFESP Google Scholar
Morales, Yael Google Scholar
Cabral, Thiago Autor UNIFESP Google Scholar
Abstract Purpose. To study the safety of intravitreal injections of poly-N-isopropylacrylamide (pNIPAM) tissue adhesive in rabbit eyes. Methods. Twelve study rabbits received an intravitreal injection of 0.1mL 50% pNIPAM in the right eye. Follow-up examinations included color fundus photography, fundus fluorescein angiography (FA), optical coherence tomography (OCT), and electroretinography (ERG). Subsequent to the last follow-up assessment, the rabbits were sacrificed and histopathological study on the scleral incision sites was performed. Results. All study animals developed mild to moderate levels of inflammatory reaction in the conjunctiva, anterior chamber, and the anterior vitreous during the first month of follow-up. After this period, the level of the inflammatory reaction progressively decreased and completely disappeared after the third month of follow-up. The lens and cornea remained clear during the entire follow-up period. OCT and FA did not show areas of retinal damage or neovascularization. Histological and ERG studies of eyes injected with pNIPAM demonstrated absence of retinal toxicity. Conclusion. Intravitreal injections of pNIPAM were nontoxic in this animal study, and pNIPAM may be safe to be used as a bioadhesive in certain retinal diseases.
Keywords Transvitreal Cyanoacrylate Retinoplexy
Thermally Responsive Polymers
Tissue Adhesive
Retinal-Detachment
Fibrin Glue
Corneal Perforations
Glaucoma Therapy
Cataract-Surgery
Drug-Delivery
Management
Language English
Sponsor Research to Prevent Blindness, NIH Core [EY03040]
NSF [EEC 0310723]
Grant number Research to Prevent Blindness, NIH Core: EY03040
NSF: EEC 0310723
Date 2016
Published in Journal Of Ophthalmology. New York, 2016.
ISSN 2090-004X (Sherpa/Romeo, impact factor)
Publisher Hospital Clinicas, Univ Sao Paulo
Origin http://dx.doi.org/10.1155/2016/5356371
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000387713500001
URI http://repositorio.unifesp.br/handle/11600/49352

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