Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

Author Cadegiani, Flavio A. Autor UNIFESP Google Scholar
Silva, Osvalmir Sa Google Scholar
Abstract Objective: Acarbose is a glucosidase inhibitor that slows carbohydrate digestion. It could thus be effective to promote remission of dumping syndrome (DS). Previous studies associating acarbose and late dumping, although not early dumping, have been reported. Herein, we aimed to evaluate the role of acarbose in dumping syndrome prevention and treatment and in resistive exercises resistance in bariatric subjects. Methods: Bariatric patients with DS and complete adherence to diet plan and resistive exercises were included (n=25). Number of early and late episodes, self-referred intensity of each episode, and ability to increase intensity of resistive exercise were evaluated, on a 0-10 scale. Acarbose was administered orally (50 mg) for 6 months, 4-5 times a day before meals. Results: Acarbose administration was associated with a decrease in the number of early (2.18-0.31) and late (2.79-0.12) episodes per week and intensity of each episode (6.10-1.65) and an increase in the ability to perform resistive exercises (3.03-7.12). Complete remission of DS was seen in 21 patients (84%), which persisted for 6 months with the use of acarbose. Conclusion: Acarbose prevented dumping in almost all studied subjects and helped improve exercise capacity.
Keywords Dumping Syndrome
Bariatric Surgery
Post-Bariatric
ObesityGastric Bypass
Hypoglycemia
Diagnosis
Pathophysiology
Octreotide
Surgery
Therapy
Language English
Date 2016
Published in Diabetes Metabolic Syndrome And Obesity-Targets And Therapy. Albany, v. 9, p. 443-446, 2016.
ISSN 1178-7007 (Sherpa/Romeo, impact factor)
Publisher Czech Acad Sci, Inst Entomology
Extent 443-446
Origin https://doi.org/10.2147/DMSO.S123244
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000389895400001
URI http://repositorio.unifesp.br/handle/11600/49329

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