Characterization of intracranial pressure behavior in chronic epileptic animals: a preliminary study

Characterization of intracranial pressure behavior in chronic epileptic animals: a preliminary study

Author Cardim, Danilo Augusto Google Scholar
Frigieri, Gustavo Henrique Google Scholar
Troca Cabella, Brenno Caetano Google Scholar
Malheiros, Jackeline Moraes Autor UNIFESP Google Scholar
Cardim, Ana Carolina Google Scholar
Wang, Charles Chenwei Google Scholar
Pacheco Andrade, Rodrigo de Albuquerque Google Scholar
Covolan, Luciene Autor UNIFESP Google Scholar
Tannus, Alberto Google Scholar
Mascarenhas, Sergio Google Scholar
Abstract Intracranial pressure (ICP) is a major neurological parameter in animals and humans. ICP is a function of the relationship between the contents of the cranium (brain parenchyma, cerebrospinal fluid, and blood) and the volume of the skull. Increased ICP can cause serious physiological effects or even death in patients who do not quickly receive proper care, which includes ICP monitoring. Epilepsies are a set of central nervous system disorders resulting from abnormal and excessive neuronal discharges, usually associated with hypersynchronism and/or hyperexcitability. Temporal lobe epilepsy (TLE) is one of the most common forms of epilepsy and is also refractory to medication. ICP characteristics of subjects with epilepsy have not been elucidated because there are few studies associating these two important neurological factors. In this work, an invasive (ICPi) and the new minimally invasive (ICPmi) methods were used to evaluate ICP features in rats with chronic epilepsy, induced by the experimental model of pilocarpine, capable of generating the main features of human TLE in these animals.
Keywords Intracranial Pressure
Epilepsy
Icp
Icp Monitoring
PilocarpineTemporal-Lobe Epilepsy
Pilocarpine Model
Seizures
Damage
Rats
Language English
Date 2016
Published in Intracranial Pressure And Brain Monitoring Xv. Dordrecht, v. 122, p. 329-333, 2016.
ISSN 0065-1419 (Sherpa/Romeo, impact factor)
Publisher Univ Estadual Oeste Parana-Unioeste
Extent 329-333
Origin http://dx.doi.org/10.1007/978-3-319-22533-3_65
Access rights Closed access
Type Conference paper
Web of Science ID WOS:000390281000065
URI http://repositorio.unifesp.br/handle/11600/49318

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