Egfr and eml4-alk updated therapies in non-small cell lung cancer

Egfr and eml4-alk updated therapies in non-small cell lung cancer

Author de Mello, Ramon Andrade Google Scholar
Liu, Davi J. J. Autor UNIFESP Google Scholar
Aguiar, Pedro N., Jr. Autor UNIFESP Google Scholar
Tadokoro, Hakaru Autor UNIFESP Google Scholar
Abstract Background: Non-small cell lung cancer is the leading cancer-related cause of death. Objective: We review the latest therapies for NSCLC with EGFR and ELM4-ALK mutations as well as the most relevant studies and promising patents. Method: A literature search of PubMed database was carried out to identify recent Clinical Trials using EGFR therapies and novel patents involving diagnosis and therapies on NSCLC. We conducted a search to find new therapy strategies, new biomarkers, and selected five patents we find relevant. Results: Over the last few years, identification of cancer harboring epidermal growth factor receptor mutations (EGFR) or chromosomal rearrangements of anaplastic lymphoma kinase (ALK) led to new ways in classifying and treating NSCLC. On the other hand, acquired resistance are a constantly challenge in the management of patients with these mutations and new drugs options are in development to improve and amplify treatment strategies. Conclusions: Currently, EGFR TKIs (e. g.: erlotinib, gefitinib, osimertinib) and ALK inhibitors (crizotinib, ceritinib, alectinib) provided a new face for advanced NSCLC outcomes. To understand the disease molecular profile is mandatory to define the best approach for each patient.
Keywords Afatinib
Egfr
Elm4-Alk
Erlotinib
Geftinib
Non-Small Cell Lung Cancer
Osimertinib
PatentTyrosine Kinase Inhibitors
T790m Mutation
1st-Line Treatment
Open-Label
Phase-Iii
Chemotherapy
Gefitinib
Erlotinib
Trial
Crizotinib
Language English
Date 2016
Published in Recent Patents On Anti-Cancer Drug Discovery. Sharjah, v. 11, n. 4, p. 393-400, 2016.
ISSN 1574-8928 (Sherpa/Romeo, impact factor)
Publisher Amer Inst Physics
Extent 393-400
Origin http://dx.doi.org/10.2174/1574892811666160803090944
Access rights Closed access
Type Revisão
Web of Science ID WOS:000395705700004
URI http://repositorio.unifesp.br/handle/11600/49265

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