Serum endocan levels associated with hypertension and loss of renal function in pediatric patients after two years from renal transplant

Serum endocan levels associated with hypertension and loss of renal function in pediatric patients after two years from renal transplant

Author de Souza, Livia Victorino Autor UNIFESP Google Scholar
Oliveira, Vanessa Autor UNIFESP Google Scholar
Laurindo, Aline Oliveira Autor UNIFESP Google Scholar
Huarachi, DelmaRegina Gomes Autor UNIFESP Google Scholar
Koch Nogueira, Paulo Cesar Autor UNIFESP Google Scholar
Feltran, Luciana de Santis Autor UNIFESP Google Scholar
Medina-Pestana, Jose Osmar Autor UNIFESP Google Scholar
Franco, Andmaria do Carmo Autor UNIFESP Google Scholar
Abstract Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients' blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: r = 0.416

P = 0.001

pulse pressure: r = 0.412

P = 0.003). The endocan levels were inversely correlated with the estimated glomerular filtration rate (r = -0.388

P = 0.003). An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity. In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function. The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.
Keywords Chronic Kidney-Disease
Glomerular-Filtration-Rate
Endothelial Dysfunction
Inflammatory Indicator
Children
Survival
Atherosclerosis
Recipients
Pressure
Marker
Language English
Sponsor FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil) [2013/03139-0]
CNPq (Conselho-Nacional de Desenvolvimento Cientifico e Tecnologico) [443248/2014-1]
Grant number FAPESP: 2013/03139-0
CNPq: 443248/2014-1
Date 2016
Published in International Journal Of Nephrology. London, 2016.
ISSN 2090-214X (Sherpa/Romeo, impact factor)
Publisher Dove Medical Press Ltd
Origin http://dx.doi.org/10.1155/2016/2180765
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000397868700001
URI http://repositorio.unifesp.br/handle/11600/49263

Show full item record




File

Name: WOS000397868700001.pdf
Size: 1.529Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account