Clinical management of localized bcg adverse events in children

Clinical management of localized bcg adverse events in children

Author Moreira, Thais das Neves Fraga Autor UNIFESP Google Scholar
de Moraes-Pinto, Maria Isabel Autor UNIFESP Google Scholar
Costa-Carvalho, Beatriz Tavares Autor UNIFESP Google Scholar
Grumach, Anete Sevciovic Google Scholar
Weckx, Lily Yin Autor UNIFESP Google Scholar
Abstract BCG adverse events (BCG-AE) are rare conditions with no well-established treatment. This study aims to describe clinical characteristics and outcome of localized BCG-AE. Children with BCG-AEs who were treated at the Reference Center for Special Immunobiologicals of the Federal University of Sao Paulo from 2009 to 2011 were included. Patients were followed monthly until 3 months after healing. One hundred and twenty-seven patients with localized BCG-AE were followed: 67 (52.7%) had suppurative lymphadenitis

30 (23.6%) injection-site abscess

five (3.9%) had enlarged lymph node > 3 cm

four (3.1%) had ulcer > 1 cm

and one (0.8%) had a local bacterial infection. Five patients (3.9%) had more than one BCG-AE simultaneously. Fifteen patients (11.8%) had atypical manifestations: seven wart-like lesions

five BCG reactivations

two other dermatologic lesions and one with vasomotor phenomenon. Isoniazid was used in 96 patients with typical BCG-AE (85.7%) until lesion resolution which took place 3.1 months later (in median)

the healing rate was 90.6%. Patients with atypical manifestations had an individual approach. Regarding the outcome, 105/112 patients with typical AE and 13/15 patients with atypical AE had resolution of BCG-AE. Localized BCG-AE caused by BCG Moreau RJ had positive outcome when treated with a short course of isoniazid. Atypical BCG-AE are not infrequent.
Keywords Bcg Vaccine
Adverse Event
Mycobacterium BovisSevere Combined Immunodeficiency
Calmette-Guerin Vaccine
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [11/21754-8]
Grant number FAPESP: 11/21754-8
Date 2016
Published in Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao paulo, v. 58, p. UNSP 84, 2016.
ISSN 0036-4665 (Sherpa/Romeo, impact factor)
Publisher Ios Press
Extent UNSP 84
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000396241000034
SciELO ID S0036-46652016005000266 (statistics in SciELO)

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