Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior

Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior

Author Takada, Silvia Honda Google Scholar
Motta-Teixeira, Livia Clemente Google Scholar
Machado-Nils, Aline Vilar Google Scholar
Lee, Vitor Yonamine Google Scholar
Sampaio, Carlos Alberto Google Scholar
Polli, Roberson Saraiva Autor UNIFESP Google Scholar
Malheiros, Jackeline Moraes Autor UNIFESP Google Scholar
Takase, Luiz Fernando Google Scholar
Kihara, Alexandre Hiroaki Google Scholar
Covolan, Luciene Autor UNIFESP Google Scholar
Xavier, Gilberto Fernando Google Scholar
Nogueira, Maria Ines Google Scholar
Abstract Neonates that suffer oxygen deprivation during birth can have long lasting cognitive deficits, such as memory and learning impairments. Hippocampus, one of the main structures that participate in memory and learning processes, is a plastic and dynamic structure that conserves during life span the property of generating new cells which can become neurons, the so-called neurogenesis. The present study investigated whether a model of rat neonatal anoxia, that causes only respiratory distress, is able to alter the hippocampal volume, the neurogenesis rate and has functional implications in adult life. MRI analysis revealed significant hippocampal volume decrease in adult rats who had experienced neonatal anoxia compared to control animals for rostra!, caudal and total hippocampus. In addition, these animals also had 55.7% decrease of double-labelled cells to BrdU and NeuN, reflecting a decrease in neurogenesis rate. Finally, behavioral analysis indicated that neonatal anoxia resulted in disruption of spatial working memory, similar to human condition, accompanied by an anxiogenic effect. The observed behavioral alterations caused by oxygen deprivation at birth might represent an outcome of the decreased hippocampal neurogenesis and volume, evidenced by immunohistochemistry and MRI analysis. Therefore, based on current findings we propose this model as suitable to explore new therapeutic approaches. (C) 2015 Elsevier B.V. All rights reserved.
Keywords Neonatal anoxia
MRI
Hippocampal neurogenesis
Working memory
AnxietyHypoxic-Ischemic Encephalopathy
Preterm Fetal Sheep
Brain-Injury
Perinatal Asphyxia
Transient Hypoxia
Cerebral-Palsy
Spatial Memory
Model
Cells
Proliferation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/01488-9
FAPESP: 2009/51557-0
Date 2016
Published in Behavioural Brain Research. Amsterdam, v. 296, p. 331-338, 2016.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 331-338
Origin http://dx.doi.org/10.1016/j.bbr.2015.08.039
Access rights Closed access
Type Article
Web of Science ID WOS:000366079100042
URI http://repositorio.unifesp.br/handle/11600/46099

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