Mesenchymal stem cells and chronic renal artery stenosis

Mesenchymal stem cells and chronic renal artery stenosis

Author Oliveira-Sales, Elizabeth B. Autor UNIFESP Google Scholar
Boim, Mirian A. Autor UNIFESP Google Scholar
Abstract Renal artery stenosis is the main cause of renovascular hypertension and results in ischemic nephropathy characterized by inflammation, oxidative stress, microvascular loss, and fibrosis with consequent functional failure. Considering the limited number of strategies that effectively control renovascular hypertension and restore renal function, we propose that cell therapy may be a promising option based on the regenerative and immunosuppressive properties of stem cells. This review addresses the effects of mesenchymal stem cells (MSC) in an experimental animal model of renovascular hypertension known as 2 kidney-1 clip (2K-1C). Significant benefits of MSC treatment have been observed on blood pressure and renal structure of the stenotic kidney. The mechanisms involved are discussed.
Keywords renal sympathetic nerve
renin-angiotensin system
renovascular hypertension
cell therapy
renal ischemiaExperimental Renovascular Disease
Endothelial Progenitor Cells
Angiotensin-Ii
Oxidative Stress
Nervous-System
Rat Model
Hypertension
Injury
Mechanisms
Senescence
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação Oswaldo Ramos (FOR)
Date 2016
Published in American Journal Of Physiology-Renal Physiology. Bethesda, v. 310, n. 1, p. F6-F9, 2016.
ISSN 1931-857X (Sherpa/Romeo, impact factor)
Publisher Amer Physiological Soc
Extent F6-F9
Origin http://dx.doi.org/10.1152/ajprenal.00341.2015
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000366593500002
URI http://repositorio.unifesp.br/handle/11600/46088

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