Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy

Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy

Author Reyes-Garcia, Selvin Z. Autor UNIFESP Google Scholar
Scorza, Carla Alessandra Autor UNIFESP Google Scholar
Araujo, Noemi S. Autor UNIFESP Google Scholar
Ortiz-Villatoro, Nancy N. Autor UNIFESP Google Scholar
Jardim, Anaclara Prada Autor UNIFESP Google Scholar
Centeno, Ricardo Silva Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Faber, Jean Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Abstract Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE. Five types of epileptiform-like activity were observed: interictal-like events

periodic ictal spiking

seizure-like events

spreading depression-like events

tonic seizure-like events and no activity. Different susceptibilities to generate epileptiform activity among hippocampal regions were observed

the dentate gyrus was the most susceptible region followed by the subiculum, CA4, CA1, CA2 and CA3. The incidence of epileptiform activity pattern was associated with specific regions of the hippocampal formation. Moreover, it was observed that each region of the hippocampal formation exhibits frequency-specific ranges in each subfield of the sclerotic human tissue. In conclusion, this study demonstrates that epileptiform-like activity may be induced in different regions of the hippocampal formation, including regions that are severely affected by neuronal loss.
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
FAPESP/CNPq/MCT-Instituto Nacional de Neurociencia Translacional
Universidad Nacional Autonoma de Honduras
Grant number FAPESP: 15/24691-8
FAPESP/CNPq/MCT: 573604/2008-8
UNAH: CU-O-041-05-2014
Date 2018
Published in Scientific Reports. London, v. 8, p. -, 2018.
ISSN 2045-2322 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent -
Origin http://dx.doi.org/10.1038/s41598-018-25378-9
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000431622100020
URI http://repositorio.unifesp.br/handle/11600/46043

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