A schizophrenia-like behavioral trait in the SHR model: Applying confirmatory factor analysis as a new statistical tool

A schizophrenia-like behavioral trait in the SHR model: Applying confirmatory factor analysis as a new statistical tool

Author Peres, Fernanda Fiel Autor UNIFESP Google Scholar
Eufrasio, Rai Alvares Autor UNIFESP Google Scholar
Gouvea, Douglas Albuquerque Autor UNIFESP Google Scholar
Dian, Mariana Cepollaro Autor UNIFESP Google Scholar
Santos, Camila Mauricio Autor UNIFESP Google Scholar
Swardfager, Walter Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Cogo-Moreira, Hugo Autor UNIFESP Google Scholar
Abstract Questionnaires that assess symptoms of schizophrenia patients undergo strict statistical validation, often using confirmatory factor analysis (CFA). CFA allows testing the existence of a trait that both collectively explains the symptoms and gathers the information in a single general index. In rodents, some behaviors are used to model psychiatric symptoms, but no single test or paradigm adequately captures the disorder's phenotype in toto. This work investigated the existence of a behavioral trait in the SHR strain underlying five behavioral tasks used in schizophrenia animal studies and altered in this strain: locomotor activity, rearing behavior, social interaction, prepulse inhibition of startle and contextual fear conditioning. The analysis was conducted on a sample of Wistar (n= 290) and Spontaneously Hypertensive Rats (SHRs, n= 290). CFA showed the existence of a continuous trait in both strains, and higher values among SHRs. This work is the first to demonstrate the existence of a schizophrenia-like trait in an animal model. We suggest that using CFA to evaluate behavioral parameters in animals might facilitate the pre-clinical investigation of psychiatric disorders, diminishing the gap between animal and human studies.
Keywords Confirmatory factor analysis
Animal model
Schizophrenia
Spontaneously hypertensive rat
Latent trait
Language English
Date 2018
Published in Progress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 85, p. 16-22, 2018.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 16-22
Origin http://dx.doi.org/10.1016/j.pnpbp.2018.03.021
Access rights Closed access
Type Article
Web of Science ID WOS:000432864900003
URI http://repositorio.unifesp.br/handle/11600/45961

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