Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3

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dc.contributor.author Chaves, Matheus Andrade
dc.contributor.author Oseliero Filho, Pedro Leonidas
dc.contributor.author Jange, Camila Garcia
dc.contributor.author Sinigaglia-Coimbra, Rita [UNIFESP]
dc.contributor.author Oliveira, Cristiano Luis Pinto
dc.contributor.author Pinho, Samantha Cristina
dc.date.accessioned 2018-07-26T12:18:24Z
dc.date.available 2018-07-26T12:18:24Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1016/j.colsurfa.2018.04.018
dc.identifier.citation Colloids And Surfaces A-Physicochemical And Engineering Aspects. Amsterdam, v. 549, p. 112-121, 2018.
dc.identifier.issn 0927-7757
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/45957
dc.description.abstract This study aimed the production of multilamellar liposomes coencapsulating two hydrophobic bioactives, curcumin and vitamin D-3, which present antioxidant and nutraceutical properties. Liposomes were produced by proliposomes hydration and stabilized with a mixture of xanthan and guar gums. Proliposomes were produced by coating of micronized sucrose method. Physicochemical properties of the dispersions were evaluated over 42 days of refrigerated storage. Microstructural characterization were performed by differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS) and small deformation rheological analyses. Liposomes showed spherical and near-spherical shapes and presented hydrodynamic diameters in the 680-1580 nm range. Curcumin and cholecalciferol were loaded into the same vesicles, with preservation efficiencies ranging from 89.6 to 93.3% and from 88.3 to 91.3%, respectively, after 42 days of storage. SAXS data showed that the lipid bilayer of liposomes produced in the presence of curcumin, vitamin D-3, or a mixture of both, are very similar. Also, higher amounts of vitamin D-3 did not affect negatively the stability of phospholipid vesicles. Overall, it was demonstrated that the coencapsulation of curcumin and vitamin D-3 by liposomes is feasible and high contents of bioactives were retained throughout the storage time. en
dc.description.sponsorship FAPESP
dc.description.sponsorship CAPES (Coordination of Improvement of Staff Level Superior, BR)
dc.description.sponsorship CNPq (National Council for Scientific and Technological Development, BR)
dc.format.extent 112-121
dc.language.iso eng
dc.publisher Elsevier Science Bv
dc.rights Acesso restrito
dc.subject Microencapsulation en
dc.subject Phospholipid vesicles en
dc.subject Curcuminoid en
dc.subject Cholecalciferol en
dc.subject Proliposome en
dc.subject Small-angle X-ray scattering en
dc.title Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3 en
dc.type Artigo
dc.description.affiliation Univ Sao Paulo, Dept Food Engn, Sch Anim Sci & Food Engn, Av Duque Caxias Norte 225, Pirassununga, SP, Brazil
dc.description.affiliation Univ Sao Paulo, Inst Phys, Rua Matao 1371, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Electron Microscopy Ctr, Rua Botucatu 862, Sao Paulo, SP, Brazil
dc.description.affiliation Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 USA
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Electron Microscopy Ctr, Rua Botucatu 862, Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2015/03362-6, 2014/23376-9
dc.identifier.doi 10.1016/j.colsurfa.2018.04.018
dc.description.source Web of Science
dc.identifier.wos WOS:000432551500013



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