Are the current chronic allograft nephropathy grading systems sufficient to predict renal allograft survival?

Are the current chronic allograft nephropathy grading systems sufficient to predict renal allograft survival?

Author Moscoso-Solorzano, Grace Tamara Autor UNIFESP Google Scholar
Mastroianni Kirsztajn, Gianna Autor UNIFESP Google Scholar
Ozaki, Kikumi Suzete Autor UNIFESP Google Scholar
Araujo, Sergio Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Pacheco-Silva, Alvaro Autor UNIFESP Google Scholar
Câmara, Niels Olsen Saraiva Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hospital Universitário Central de Asturias Servicio de Nefrología
Universidade de São Paulo (USP)
Abstract A major problem in renal transplantation is identifying a grading system that can predict long-term graft survival. The present study determined the extent to which the two existing grading systems (Banff 97 and chronic allograft damage index, CADI) correlate with each other and with graft loss. A total of 161 transplant patient biopsies with chronic allograft nephropathy (CAN) were studied. The samples were coded and evaluated blindly by two pathologists using the two grading systems. Logistic regression analyses were used to evaluate the best predictor index for renal allograft loss. Patients with higher Banff 97 and CADI scores had higher rates of graft loss. Moreover, these measures also correlated with worse renal function and higher proteinuria levels at the time of CAN diagnosis. Logistic regression analyses showed that the use of angiotensin-converting enzyme inhibitor (ACEI), hepatitis C virus (HCV), tubular atrophy, and the use of mycophenolate mofetil (MMF) were associated with graft loss in the CADI, while the use of ACEI, HCV, moderate interstitial fibrosis and tubular atrophy and the use of MMF were associated in the Banff 97 index. Although Banff 97 and CADI analyze different parameters in different renal compartments, only some isolated parameters correlated with graft loss. This suggests that we need to review the CAN grading systems in order to devise a system that includes all parameters able to predict long-term graft survival, including chronic glomerulopathy, glomerular sclerosis, vascular changes, and severity of chronic interstitial fibrosis and tubular atrophy.
Keywords Renin angiotensin-converting enzyme inhibitor
Chronic allograft damage index
Banff 97
Renal allograft survival
Kidney transplantation
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao Oswaldo Ramos
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CNPq: 300324/2004-9
CNPq: 302011/2007-2
Date 2008-10-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 10, p. 896-903, 2008.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 896-903
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000261171400011
SciELO ID S0100-879X2008001000011 (statistics in SciELO)

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