Furazolidone-based triple therapy for H pylori gastritis in children

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dc.contributor.author Kawakami, Elisabete [UNIFESP]
dc.contributor.author Machado, Rodrigo Strehl [UNIFESP]
dc.contributor.author Ogata, Silvio Kazuo [UNIFESP]
dc.contributor.author Langner, Marini [UNIFESP]
dc.contributor.author Fukushima, Erika [UNIFESP]
dc.contributor.author Carelli, Anna Paula [UNIFESP]
dc.contributor.author Bonucci, Vania Claudia Guimaraes [UNIFESP]
dc.contributor.author Patricio, Francy Reis Silva [UNIFESP]
dc.date.accessioned 2018-06-18T12:15:15Z
dc.date.available 2018-06-18T12:15:15Z
dc.date.issued 2006-09-14
dc.identifier http://dx.doi.org/10.3748/WJG.v12.i34.5544
dc.identifier.citation World Journal Of Gastroenterology. Beijing: W J G Press, v. 12, n. 34, p. 5544-5549, 2006.
dc.identifier.issn 1007-9327
dc.identifier.uri http://repositorio.unifesp.br/11600/45741
dc.description.abstract AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms sufficiently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive C-13-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and C-13-urea breath test. Further clinical evaluation was performed 7 cl, 2 and 6 mo after the treatment.RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 +/- 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI,. 78.5%-91%)., All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate efficacy in H pylori treatment. The eradication rate seems to be higher in patients with duodenal ulcer. (C) 2006 The WJG Press. All rights reserved. en
dc.format.extent 5544-5549
dc.language.iso eng
dc.publisher W J G Press
dc.relation.ispartof World Journal Of Gastroenterology
dc.rights Acesso aberto
dc.subject furazolidone en
dc.subject H pylori treatment en
dc.subject gastritis en
dc.subject children en
dc.title Furazolidone-based triple therapy for H pylori gastritis in children en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Pediat,Pediat Gastroenterol Div, Pept Dis Outpatient Clin, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Pediat,Pediat Gastroenterol Div, Pept Dis Outpatient Clin, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Pathol, Sao Paulo, Brazil
dc.identifier.file WOS000240647100020.pdf
dc.identifier.doi 10.3748/WJG.v12.i24.3891
dc.description.source Web of Science
dc.identifier.wos WOS:000240647100020



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