Furazolidone-based triple therapy for H pylori gastritis in children

Furazolidone-based triple therapy for H pylori gastritis in children

Author Kawakami, Elisabete Autor UNIFESP Google Scholar
Machado, Rodrigo Strehl Autor UNIFESP Google Scholar
Ogata, Silvio Kazuo Autor UNIFESP Google Scholar
Langner, Marini Autor UNIFESP Google Scholar
Fukushima, Erika Autor UNIFESP Google Scholar
Carelli, Anna Paula Autor UNIFESP Google Scholar
Bonucci, Vania Claudia Guimaraes Autor UNIFESP Google Scholar
Patricio, Francy Reis Silva Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms sufficiently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive C-13-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and C-13-urea breath test. Further clinical evaluation was performed 7 cl, 2 and 6 mo after the treatment.RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 +/- 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI,. 78.5%-91%)., All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate efficacy in H pylori treatment. The eradication rate seems to be higher in patients with duodenal ulcer. (C) 2006 The WJG Press. All rights reserved.
Keywords furazolidone
H pylori treatment
Language English
Date 2006-09-14
Published in World Journal Of Gastroenterology. Beijing: W J G Press, v. 12, n. 34, p. 5544-5549, 2006.
ISSN 1007-9327 (Sherpa/Romeo, impact factor)
Publisher W J G Press
Extent 5544-5549
Origin http://dx.doi.org/10.3748/WJG.v12.i34.5544
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000240647100020
URI http://repositorio.unifesp.br/11600/45741

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