THE RELATIONSHIPS BETWEEN NEURONAL-ACTIVITY AND BEHAVIORAL SEIZURES INDUCED BY PALICOUREA-MARCGRAVII IN RATS

THE RELATIONSHIPS BETWEEN NEURONAL-ACTIVITY AND BEHAVIORAL SEIZURES INDUCED BY PALICOUREA-MARCGRAVII IN RATS

Author Gorniak, S. L. Google Scholar
Spinosa, H. D. Google Scholar
Cavalheiro, E. A. Google Scholar
Bortolloto, Z. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract To characterize the convulsions induced by an aqueous extract of Palicourea marcgravii (Pm), male Wistar rats were injected sc with 3.75 g/kg of the extract, and electroencephalogram and behavior were observed for periods up to 180 min after the Pm injections. Sleep spindles and generalized convulsive seizures were observed following Pm administration. Spiking activity was detected in both cortical and hippocampus recordings. They lasted approximately 2 min and were followed by a period of postical depression and/or death. These results agreed with previous behavioral experiments which suggested the toxic effect of Pm aqueous extract was mainly at the central nervous system level.
Language English
Date 1992-10-01
Published in Veterinary And Human Toxicology. Manhattan: Comparative Toxicology Lab, v. 34, n. 5, p. 401-402, 1992.
ISSN 0145-6296 (Sherpa/Romeo, impact factor)
Publisher Comparative Toxicology Lab
Extent 401-402
Access rights Closed access
Type Article
Web of Science ID WOS:A1992JQ02800003
URI http://repositorio.unifesp.br/11600/45727

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