Associated or combined vaccination of Brazilian infants with a conjugate Haemophilus influenzae type b (Hib) vaccine, a diphtheria-tetanus-whole-cell pertussis vaccine and IPV or OPV elicits protective levels of antibodies against Hib

Associated or combined vaccination of Brazilian infants with a conjugate Haemophilus influenzae type b (Hib) vaccine, a diphtheria-tetanus-whole-cell pertussis vaccine and IPV or OPV elicits protective levels of antibodies against Hib

Author Araujo, Orlei O. Autor UNIFESP Google Scholar
Forleo-Neto, Eduardo Google Scholar
Vespa, Glaucia NR Google Scholar
Puccini, Rosana F. Autor UNIFESP Google Scholar
Weckx, Lilly W. Autor UNIFESP Google Scholar
Carvalho, Eduardo S. Autor UNIFESP Google Scholar
Farhat, Calil K. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Pasteur Merieux Connaught Brasil
Abstract This study investigated the immunogenicity and safety of including a Haemophilus influenzae type b vaccine (polyribosylribitol phosphate conjugated to tetanus toroid, PRP-T) in three different vaccination schemes: (1) PRP-T reconstituted with a combined diphtheria-tetanus-pertussis-inactivated poliovirus vaccine (DTP-IPV//PRP-T); (2) PRP-T reconstituted with DTP and administered concomitantly with an oral poliovirus vaccine (DTP//PRP-T+OPV); and (3) PRP-T administered concomitantly with DTP at a different injection site and OPV (DTP + PRP-T + OPV). Vaccines were given at 2, 4, and 6 months of age. A total of 252 infants were enrolled, and randomly assigned to one of the three vaccination groups (84 infants in each group); 241 infants were followed until the end of the study. Antibody production against PRP, diphtheria, tetanus and pertussis antigens was satisfactory for each vaccination scheme used. A good response to Hib vaccine was elicited in each group, and 3 months after the third vaccine dose, at least 97% of children in each group had levels of PRP antibody considered to be seroprotective (>0.15 mu g/ml), and over 90% of children in each group had levels over 1.0 mu g/ml. The solicited local and systemic adverse events following vaccination were mild in all groups and resolved within 4 days without medical intervention. With the exception of fever, which was more common after the second dose in children who received DTP-IPV//PRP-T, local and systemic reactions did not differ between the vaccination groups. Due to the practical advantages of combined vaccines, their use in routine immunization programs in developing countries is highly desirable. Our results show that Hib conjugate vaccine can be included in routine immunization programs that include either OPV or IPV with satisfactory immunogenicity and safety profiles. This flexible approach should facilitate the inclusion of the Hib conjugate vaccine in routine immunization programs on a world-wide scale. (C) 2000 Elsevier Science Ltd. All rights reserved.
Keywords Haemophilus influenzae type b vaccine
poliomyelitis vaccine
diphtheria-tetanus-pertussis vaccine
Language English
Date 2000-09-15
Published in Vaccine. Oxford: Elsevier Sci Ltd, v. 19, n. 2-3, p. 367-375, 2000.
ISSN 0264-410X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 367-375
Origin http://dx.doi.org/10.1016/S0264-410X(00)00093-1
Access rights Closed access
Type Article
Web of Science ID WOS:000089237000027
URI http://repositorio.unifesp.br/11600/45722

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