COMPARISON OF 3 DIFFERENT SCHEDULES OF VACCINATION AGAINST HEPATITIS-B IN HEALTH-CARE WORKERS

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dc.contributor.author Oliveira, Patricia MC [UNIFESP]
dc.contributor.author Silva, A. Eduardo [UNIFESP]
dc.contributor.author Kemp, Vitorio L. [UNIFESP]
dc.contributor.author Juliano, Yara [UNIFESP]
dc.contributor.author Ferraz, M. Lucia [UNIFESP]
dc.date.accessioned 2018-06-18T12:15:12Z
dc.date.available 2018-06-18T12:15:12Z
dc.date.issued 1995-06-01
dc.identifier http://dx.doi.org/10.1016/0264-410X(94)00064-T
dc.identifier.citation Vaccine. Oxford: Butterworth-heinemann Ltd, v. 13, n. 9, p. 791-794, 1995.
dc.identifier.issn 0264-410X
dc.identifier.uri http://repositorio.unifesp.br/11600/45721
dc.description.abstract Health cave workers (HCW) are a group at risk for hepatitis B virus (HBV) infection; as a result, vaccination is recommended. However, elevated cost of the vaccination schedule is one of the limiting factors to this approach. Our aim in this study was to evaluate alternative schedules for vaccination against hepatitis B, in order to obtain safe immunization with reduced costs. We studied 300 HCW, randomized to be submitted to one of three vaccination schedules against hepatitis B: Group A-three doses of 20 mu g i. m. (n=103); Group B-first dose i.d. (2 mu g), second and third doses im. (20 mu g) (n=97), Group C-first and second doses i.d. (2 mu g), third dose i.m. (20 mu g) (n=100). All individuals received recombinant vaccine at 0, 1 and 6 months. After the first dose, there was no difference among the three schedules, either in terms of anamnestic response or in seroconversion rate. After the second dose, there was statistical difference among the three schedules (A>B>C), in terms of seroconversion rates. After the third dose, seroconversion rates were 92.2% in Group A and 92.8% in group B; geometric mean titers (GMT) in Group B (789.6 UI l(-1) were similar to group A (1248.0 UI l(-1)). Group C presented a seroconversion rate of 78% and a GMT of 323.0 UI l(-1), both statistically inferior to other schedules. We concluded that the schedule applied in Group B had similar results when compared to schedule A, with estimated savings of 30% in vaccine costs. However, a long-term follow-up is necessary to evaluate its cost-effectiveness. en
dc.format.extent 791-794
dc.language.iso eng
dc.publisher Butterworth-heinemann Ltd
dc.relation.ispartof Vaccine
dc.rights Acesso restrito
dc.subject HEPATITIS B en
dc.subject HEPATITIS B VACCINE en
dc.subject IMMUNIZATION en
dc.title COMPARISON OF 3 DIFFERENT SCHEDULES OF VACCINATION AGAINST HEPATITIS-B IN HEALTH-CARE WORKERS en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED,DIV BIOSTAT,SAO PAULO,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DIV BIOSTAT,SAO PAULO,BRAZIL
dc.identifier.doi 10.1016/S0090-4295(00)00615-4
dc.description.source Web of Science
dc.identifier.wos WOS:A1995RL56600001



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