Dopamine Transporter Regulation during Four Nights of REM Sleep Deprivation Followed by Recovery - An in vivo Molecular Imaging Study in Humans

Dopamine Transporter Regulation during Four Nights of REM Sleep Deprivation Followed by Recovery - An in vivo Molecular Imaging Study in Humans

Author Martins, R. C. S. Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Garbuio, Silvério Aparecido Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Guindalini, Camila Autor UNIFESP Google Scholar
Shih, M. C. Autor UNIFESP Google Scholar
Hoexter, M. Q. Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca. A. Autor UNIFESP Google Scholar
Castiglioni, M. L. V. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objectives: To assess the influence of total or selective REM sleep deprivation on the dopamine transporter (DAT) densities and sleep patterns of healthy volunteers.Design: Prospective study.Setting: Evaluation of polysomnography recordings and DAT density after 4 nights of selective REM sleep deprivation followed by 3 nights of sleep recovery compared to a control group and a group that was subjected to 2 nights of total sleep deprivation. Single positron emission computed tomography and [(99m)Tc]TRODAT-1 were used to assess the cerebral DAT density in the striatum at baseline, after REM sleep deprivation and total sleep deprivation as well as after sleep recovery. Blood was collected daily to examine prolactin and estradiol levels, which were correlated with dopaminergic activity.Patients or Participants: Thirty healthy male volunteers ranging from 19 to 29 years of age were randomly assigned to one of three experimental groups after giving written informed consent (10 non-sleep deprived, 10 total sleep deprived, and 10 REM sleep deprived).Measurements and Results: Four nights of REM sleep deprivation and 2 nights of total sleep deprivation induced distinct and heterogeneous patterns of sleep recovery. No significant modulation of DAT availability was observed within groups. In the recovery nights, changes in cortisol, prolactin and estradiol concentrations were significantly correlated with specific sleep stages in the total and REM sleep deprived groups. In addition, DAT density was positively correlated with estradiol concentration and inversely associated with SWS latency only after total sleep deprivation.Conclusion: Our study demonstrates that although sleep deprivation did not promote significant alterations in DAT density within the striatum, there were significant correlations among transporter availability, hormonal concentrations and sleep parameters.
Keywords Sleep deprivation
recovery
SPECT
dopamine
prolactin
estradiol
rebound sleep
TRODAT
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 98/14303-3
FAPESP: 06/58276-8
Date 2010-02-01
Published in Sleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 2, p. 243-251, 2010.
ISSN 0161-8105 (Sherpa/Romeo, impact factor)
Publisher Amer Acad Sleep Medicine
Extent 243-251
Origin https://doi.org/10.1093/sleep/33.2.243
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000274364500015
URI http://repositorio.unifesp.br/11600/45608

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