Effects of Sleep Deprivation on Memory in Mice: Role of State-Dependent Learning

Effects of Sleep Deprivation on Memory in Mice: Role of State-Dependent Learning

Author Patti, Camilla L. Autor UNIFESP Google Scholar
Zanin, Karina A. Autor UNIFESP Google Scholar
Sanday, Leandro Autor UNIFESP Google Scholar
Kameda, Sonia R. Autor UNIFESP Google Scholar
Fernandes-Santos, Luciano Autor UNIFESP Google Scholar
Fernandes, Helaine A. Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Study Objectives: A considerable amount of experimental evidence suggests that sleep plays a critical role in learning/memory processes. In addition to paradoxical sleep, slow wave sleep is also reported to be involved in the consolidation process of memories. Additionally, sleep deprivation can induce other behavioral modifications, such as emotionality and alternations in locomotor activity in rodents. These sleep deprivation-induced alterations in the behavioral state of animals could produce state-dependent learning and contribute, at least in part, to the amnestic effects of sleep deprivation. The aim of the present study was to examine the participation of state-dependent learning during memory impairment induced by either paradoxical sleep deprivation (PSD) or total sleep deprivation (TSD) in mice submitted to the plus-maze discriminative avoidance or to the passive avoidance task.Design: Paradoxical sleep deprivation (by the multiple platform method) and total sleep deprivation (by the gentle handling method) were applied to animals before training and/or testing.Conclusions: Whereas pre-training or pre-test PSD impaired retrieval in both memory models, pre-training plus pre-test PSD counteracted this impairment. For TSD, pre-training, pre-test, and pre-training plus pre-test TSD impaired retrieval in both models. Our data demonstrate that PSD(but not ISO-) memory deficits are critically related to state-dependent learning.
Keywords Sleep
memory
state-dependency
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Associacao Fundo de Pesquisa em Psicobiologia (AFIP)
Date 2010-12-01
Published in Sleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 12, p. 1669-1679, 2010.
ISSN 0161-8105 (Sherpa/Romeo, impact factor)
Publisher Amer Acad Sleep Medicine
Extent 1669-1679
Origin https://doi.org/10.1093/sleep.33.12.1669
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000284719900012
URI http://repositorio.unifesp.br/11600/45607

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