Sleep Restriction during Pregnancy: Hypertension and Renal Abnormalities in Young Offspring Rats

Sleep Restriction during Pregnancy: Hypertension and Renal Abnormalities in Young Offspring Rats

Author Thomal, Janaina Thais Autor UNIFESP Google Scholar
Palma, Beatriz Duarte Autor UNIFESP Google Scholar
Ponzio, Beatriz Felice Autor UNIFESP Google Scholar
Pinho Franco, Maria do Carmo Autor UNIFESP Google Scholar
Zaladek-Gil, Frida Autor UNIFESP Google Scholar
Fortes, Zuleica Bruno Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Gomes, Guiomar Nascimento Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Study Objectives: Because the maternal environment can affect several physiological functions of the newborn, the aim of the present study was to examine the impact of sleep restriction during pregnancy on renal morphology and function in young offspring.Design: Female 3-month-old Wistar rats were divided in 2 experimental groups: C (control) and SR (sleep restriction between the 14th and 20th day of pregnancy). Pregnancy was confirmed by vaginal smear. SR females were subjected to sleep restriction by the multiple platform technique for 20 h daily. After birth, only male litters (6 for each mother) were selected and designated OC (offspring from C) and OSR (offspring from SR). At 2 months of age, blood pressure (BP) was measured by tail plethysmography; at 3 months the renal plasma flow (RPF), glomerular filtration rate (GFR), glomerular area, and number of glomeruli per mm(3) were evaluated.Measurements and Results: Offspring from SR had higher systolic blood pressure than OC. In this group (OSR), we also observed significant increase in RPF and GFR, enlarged glomeruli diameter, and reduced number of glomeruli per mm3 of renal tissue.Conclusions: Our data suggest that sleep restriction during pregnancy is able to modify renal development, resulting in morphologic and functional alterations in young offspring.
Keywords Sleep
renal function
glomerular hypertrophy
hypertension
fetal programming
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Date 2010-10-01
Published in Sleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 10, p. 1357-1362, 2010.
ISSN 0161-8105 (Sherpa/Romeo, impact factor)
Publisher Amer Acad Sleep Medicine
Extent 1357-1362
Origin https://doi.org/10.1093/sleep/33.10.1357
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000282249700013
URI http://repositorio.unifesp.br/11600/45605

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