Verbal ability impairment in juvenile systemic lupus erythematosus

Verbal ability impairment in juvenile systemic lupus erythematosus

Title: Verbal ability impairment in juvenile systemic lupus erythematosus;
Comprometimento da habilidade verbal no lúpus eritematoso sistêmico juvenil
Author Santos, Maria Carolina dos Google Scholar
Okuda, Eunice Mitiko Google Scholar
Ronchezel, Marcos Vinicius Autor UNIFESP Google Scholar
Leon, Elaine Pires Google Scholar
Trindade, Vilma dos Santos Autor UNIFESP Google Scholar
Bastos, Wanda Alves Google Scholar
Sacchetti, Silvana Brasilia Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction/Objective: Evaluate the frequency of verbal ability impairment and associated factors in patients with juvenile systemic lupus erythematosus (JSLE). Patients and Methods: Cross sectional study of 36 children and adolescents with JSLE of a group of 57 patients at the Clinic of Rheumatology, Department of Pediatrics and Medical Clinic of Santa Casa de Misericordia de Sao Paulo. At the time of diagnosis and study, we analyzed the following epidemiological features: clinical, socioeconomic, and educational level. Patients underwent cognitive and laboratory tests and we assessed disease activity (SLEDAI), cumulative damage (SLICC-DI), and treatment with corticosteroids. The patients underwent cognitive tests (Wechsler Intelligence Scales: WISC III and Waiss III), and the results were evaluated according to epidemiological, clinical, laboratory and treatment features. Results: The mean age at diagnosis was 11.2 +/- 2 years and at the time of the study the mean age was 15.4 +/- 4.7 years. There was predominance of women (89%) and of socioeconomic class C patients (61.1%). The cognitive impairment found in these patients was frequent (58.3%), affecting more often the verbal ability. We found association of verbal ability impairment with low socioeconomic status and cumulative damage (P < 0.05), but not with disease activity, presence of autoantibodies, and dose of corticosteroids (P > 0.05). Conclusions: Change in verbal ability is frequent in JSLE and is associated with socioeconomic status and cumulative damage, and should be suspected and investigated, particularly in pediatric patients to avoid quality of life impairment in adulthood. As it is not related with disease activity or presence of autoantibodies, it should always be assessed in the presence or absence of these factors. Likewise, the doses of corticosteroids should be independently evaluated.
Keywords systemic lupus erythematosus
cognition
child
adolescent
cognitive tests
Language Portuguese
Date 2010-07-01
Published in Revista Brasileira De Reumatologia. New York: Elsevier Science Inc, v. 50, n. 4, p. 362-374, 2010.
ISSN 0482-5004 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 362-374
Origin http://dx.doi.org/10.1590/S0482-50042010000400003
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000208389400003
SciELO ID S0482-50042010000400003 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/45408

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