Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice

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dc.contributor.author Silva, Regina Helena da [UNIFESP]
dc.contributor.author Bellot, Rogerio Gentil [UNIFESP]
dc.contributor.author Vital, Maria Aparecida Barbato Frazão [UNIFESP]
dc.contributor.author Frussa-Filho, Roberto [UNIFESP]
dc.date.accessioned 2018-06-18T11:27:20Z
dc.date.available 2018-06-18T11:27:20Z
dc.date.issued 1997-02-01
dc.identifier.citation Psychopharmacology. New York: Springer Verlag, v. 129, n. 4, p. 322-328, 1997.
dc.identifier.issn 0033-3158
dc.identifier.uri http://repositorio.unifesp.br/11600/45164
dc.description.abstract The beneficial effects of monosialoganglioside GM1 (GM1) on learning and memory have been detected mostly in animals presenting genetic, lesion-induced or age-related memory deficits. The present study was carried out to investigate the effects of GM1 on the discriminative avoidance behavior of normal adult mice. EPM-M1 male mice were treated daily IP with 50 mg/kg GM1 or saline for 14 days. The discriminative avoidance conditioning was performed on day 15 in a modified elevated plus-maze. In one of the enclosed arms, the animals received aversive stimulation (light and noise). Tests were performed on days 20, 25 and 30 (tests 1, 2 and 3). The time the animals spent in each of the enclosed arms was recorded. In tests 1 and 2, GM1-treated mice spent less time in the aversive arm in comparison to the non-aversive enclosed arm. On the other hand, control animals spent a shorter time in the aversive arm only in test 1. The results suggest that the beneficial effects of GM1 on learning and memory can be observed in normal animals as well. en
dc.format.extent 322-328
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology
dc.rights Acesso restrito
dc.subject memory en
dc.subject ganglioside en
dc.subject GM1 en
dc.subject discriminative avoidance behavior en
dc.subject mice en
dc.title Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution UNIV FED PARANA
dc.description.affiliation UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FARMACOL,SAO PAULO,BRAZIL
dc.description.affiliation UNIV FED PARANA,DEPT FARMACOL,BR-80060000 CURITIBA,PARANA,BRAZIL
dc.description.affiliationUnifesp UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FARMACOL,SAO PAULO,BRAZIL
dc.description.source Web of Science
dc.identifier.wos WOS:A1997WM04300003



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